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Icyari kigamijwe muri ubu bushakashatsi kwari ugusuzuma igipimo cyo gukuramo kine ku buryo bubiri buke bwa lazeri yo kuvura (LLLT) uburyo bwo gukwirakwiza imirasire, harimo n’umurongo mwinshi kandi muto.Abarwayi 20 bagabanijwe mu matsinda abiri.Mu itsinda A, uruhande rumwe rwububiko bwa maxillary rwateganijwe kwakira LILT kumunsi 0, 3, 7, 14, na buri byumweru 2 nyuma yaho, mugihe mumatsinda B, uruhande rumwe rwakiriye LILT mubyumweru 3.Mugihe cyibyumweru 12 byo kwiga, kugendana amenyo byagenzuwe buri byumweru bitatu uhereye igihe itangiriye.Hiyongereyeho kandi, hasuzumwe urwego rwa interleukin-1β (IL-1β) mu mazi ya gingival sulcus. Ibisubizo byagaragaje ubwiyongere bukomeye bwikigereranyo cyo gukuramo kine kumpande ya laser yitsinda A na B, ugereranije nimpande zagenzuwe (p <0.05), nta tandukaniro rikomeye ryagaragaye hagati yimpande za lazeri mumatsinda yombi (p = 0.08–0.55). Ibisubizo byagaragaje ubwiyongere bukomeye bwikigereranyo cyo gukuramo kine kumpande ya laser yitsinda A na B, ugereranije nimpande zagenzuwe (p <0.05), nta tandukaniro rikomeye ryagaragaye hagati yimpande za lazeri mumatsinda yombi (p = 0.08–0.55). Результаты вявили значительное увеличение скорости ретракции кнаков на стороне лазера в группах A и B по сравнению с черной стороной (p <0,05), شاھ существенных различий между сторонами лача. Ibisubizo byagaragaje ubwiyongere bugaragara bwumuvuduko wo gukuramo kanseri kuruhande rwa laser mumatsinda A na B ugereranije no kugenzura (p <0.05), nta tandukaniro rikomeye riri hagati yimpande za laser mumatsinda yombi (p = 0.08–0.55). ).结果 显示 ， 与 对照 组 相比 ， A 组 和 B 组 激光 侧 的 <<<<<<<<<<显示 ， 与 对照 组 ， 组 和 a 组 和 b 组 激光 侧 犬齿 <<p <0.05） Результаты показали, что по сравнению с କାନной группой скорость ретракции кнаков на стороне лазера в группах А и В б з зачительно вше (p <0,05), а на стороне лазера не было сущвегной раз ры? Ibisubizo byerekanye ko, ugereranije nitsinda rishinzwe kugenzura, igipimo cyo gukuramo kine kuruhande rwa laser mumatsinda A na B cyari hejuru cyane (p <0.05), kandi nta tandukaniro rikomeye ryari hagati yaya matsinda yombi kuruhande rwa lazeri (p = 0.08-0 .55). Na none, urwego rwa IL-1β rwari hejuru cyane kuruhande rwa laser ya matsinda yombi, ugereranije nimpande zigenzura (p <0.05). Na none, urwego rwa IL-1β rwari hejuru cyane kuruhande rwa laser ya matsinda yombi, ugereranije nimpande zigenzura (p <0.05). Кроме того, оровни IL-1β были значительно выше на стороне лазера в обеих группах по сравнению с панной стороной (p <0,05). Mubyongeyeho, urwego rwa IL-1β rwari hejuru cyane kuruhande rwa laser mumatsinda yombi ugereranije no kugenzura (p <0.05).此外 ， 与 对照 组 相比 ， 激光 侧 的 IL-1β 水平 显 着 升高 （p <0.05）。此外 ， 与 对照 组 相比 ， 激光 侧 的 IL-1β 水平 显 着 升高 （p <0.05）。 Кроме того, оровни IL-1β были значительно повышены на стороне лазера в обеих группах по сравнению с панной группой (p <0,05). Mubyongeyeho, urwego rwa IL-1β rwazamutse cyane kuruhande rwa laser mumatsinda yombi ugereranije nitsinda rishinzwe kugenzura (p <0.05).Niyo mpamvu, LILI yashoboye kwihutisha neza amenyo, yaba yarakoreshejwe kenshi cyangwa gake, ibyo bikaba byari bifitanye isano no kwiyongera kw’ibinyabuzima, ibyo bikaba byaragaragaye mu kwiyongera kwa IL-1β kuruhande.
Kuvura igihe kirekire (mubisanzwe hafi amezi 20-30) byagaragaye ko bigira ingaruka mbi ku kubahiriza abarwayi, hiyongereyeho ingaruka nka root resorption2, caries3, decalcification ya emam3 nibibazo byigihe4,5.Kubwibyo, hashyizweho uburyo bwinshi bugamije kwihutisha amenyo ya ortodontique (OTM), harimo no kubaga no kubaga.Byongeye kandi, hasuzumwe ingaruka zo guhuza uburyo bubiri bwihuta ningaruka zo gusubiramo inzira imwe yihuta kumuvuduko wa OTM6.
Ubuvuzi buke bwa lazeri (LLLT) ni bumwe mu buryo bwateganijwe bwo kubagwa mu buryo bwihuse kugira ngo OTM yihute, ariko habaye ibisubizo bivuguruzanya muri raporo zerekana ko ikora neza muri uru rwego, mu gihe inyandiko 7,8 n'ingaruka mbi zanditswe.Ibisubizo bivuguruzanya birashobora gusobanurwa nibitandukaniro mubipimo bya lazeri ikoreshwa muri buri nyigo, harimo ubwoko bwa lazeri, uburyo bwo gukoresha, uburebure bwumuraba, imishwarara yumuriro, nigihe cyo kwerekana, kubera ko ibyo bipimo bifitanye isano itaziguye nibisubizo byubuvuzi bwa lazeri 10.
Kubijyanye nuburyo bwo gukoresha, protocole zitandukanye za laser irradiation zavuzwe kugirango byorohereze amenyo.Porotokole imwe ikoreshwa cyane ikubiyemo gukoresha lazeri kumunsi 0, 3, 7, 14, 21 na 30, gusubiramo urukurikirane rumwe buri kwezi, kandi iyi protocole yemejwe nabanditsi benshi11,12.Abandi bakoresheje ubundi buryo bugereranijwe hafi yuburyo bwasobanuwe mbere kandi ni bumwe muburyo bukoreshwa cyane, aho LILI ikoreshwa kumunsi 0, 3, 7, 14, hanyuma buri minsi 15 kugeza igihe cyo kwiga kirangiye.13. Byongeye kandi, hashyizweho protocole ikubiyemo buri cyumweru ikoreshwa rya lazeri nkeya mu gihe cyo gufata kine.Nyamara, imbogamizi nyamukuru yaya protocole isanzwe nigipimo kinini cyibitekerezo byabarwayi, bishobora kutorohera buri wese.Rero, protocole isaba kohereza abarwayi bake ikoreshwa, kurugero, harimo LILI inshuro 8 mukwezi cyangwa 15, 16, 17, 18 buri byumweru 3.
Kubera ko imbaraga za ortodontique zizwiho gutera amagufwa kuvugurura, iterambere ryimpinduka zumuriro nicyo gisabwa muriki gikorwa, biganisha ku kudahuza amenyo19.Dukurikije ubushakashatsi bwinshi, bumwe mu buryo bwo gusuzuma ibinyabuzima bishobora kubaho mu gihe cya ligamento ni ugusuzuma urwego rwa cytokine mu mazi ya gingival sulcus (GCF).Interleukin-1β (IL-1β) ni cytokine ikora cyane muburyo bwo guhinduranya amagufwa kandi ifatwa nkimwe muri cytokine ikomeye cyane mugice cyambere cya OTM.Kubera ko hari isano hagati yurwego rwa IL-1β no kubaho, guhuza hamwe no gukora osteoclast, IL-1β irashobora gufatwa nkikimenyetso cyingenzi cyo kubara urugero rwimikorere yinyo ya ortodontique, ifitanye isano nuburyo bwiza bwo kuvugurura amagufwa ya alveolar24.
Kubwibyo, intego yubushakashatsi bwacu kwari ugusuzuma no kugereranya ingaruka za NILT hamwe nuburyo bukunze gukoreshwa, harimo inshuro nyinshi yo gukoresha kumunsi 0, 3, 7, 14, hanyuma buri byumweru 2 ugereranije no gukoresha buri byumweru 3.Igipimo cyo gukuramo imbwa mugerageza kugabanya inshuro zo kwibuka abarwayi.Mubyongeyeho, urwego IL-1β muri GCF rwasuzumwe hakoreshejwe protocole ebyiri.Impfabusa yubushakashatsi burimo ni uko nta tandukaniro riri hagati yo kugaruka kwa kine hamwe na LILI ukoresheje protocole ebyiri zo kwipimisha.
Ubushakashatsi bwari igeragezwa ryamavuriro ryateganijwe hamwe nitsinda ryibiri, buriwese agerageza protocole ya LILI.Buri tsinda ryemera gutandukanya umunwa, uruhande rumwe nitsinda rishinzwe kugenzura irindi ni itsinda ryiga.
Ubushakashatsi bwarimo abarwayi 20 bafite hagati yimyaka 15 na 20 bakeneye kuvanaho imiti ya premolars ya mbere yo mu rwasaya rwo hejuru, hanyuma hakurikiraho gukuramo inzoga.Ingero zingana kubara zashingiwe kumakosa ya alfa ya 5% nimbaraga zo kwiga 80%.Iyi mibare ishingiye ku gutandukanya uburyo busanzwe bwo gutandukana kwa kine mu bushakashatsi aho Doshi-Mehta na Bhad-Patil7 bakoresheje LILI ku minsi 0, 3, 7, 14 na buri byumweru 2 nyuma yaho (Arm A) no mu bushakashatsi bwa Qamruddin n'abandi.abandi Mu bushakashatsi 15, LILI yakoreshejwe buri byumweru 3 (itsinda B).Imyitwarire myiza yabonetse mu Nama ishinzwe imyitwarire y’ishami ry’amenyo, kaminuza ya Alegizandiriya, Alegizandiriya, Misiri (IRB: 00010556-IORG: 0008839).Umubare wa komite ishinzwe imyitwarire yintoki ni 0111-01 / 2020.Byemejwe ku ya 21 Mutarama 2020. Urubanza rwanditswe muri ClinicalTrials.gov nka “Porotokole ebyiri zo mu rwego rwo hasi kugira ngo dusuzume umuvuduko ukabije w'imbwa.”Numero yo kwiyandikisha yikigereranyo ni NCT04926389.Itariki yo kwiyandikisha mu rubanza ni 15/6/2021 kuri https://clinicaltrials.gov/ct2/show/NCT04926389.Kwiyandikisha kw'abarwayi muri ubwo bushakashatsi byatangiye ku ya 5 Gashyantare 2020 birangira ku ya 28 Ugushyingo 2021.
Abarwayi binjijwe mu ivuriro rya ortodontike ry’ishami ry’amenyo rya kaminuza ya Alegizandiriya.Ibintu byagenzuwe kandi bisuzumwa hifashishijwe ibipimo bikurikira byujuje ibisabwa: ubuzima rusange, kutagira indwara zidakira, nta buvuzi bwa ortodontique bwabanje, isuku ihagije yo mu kanwa, hamwe nuduce twiza twigihe.Abarwayi bitabiriye amahugurwa n'ababyeyi babo bahawe ibisobanuro byuzuye kandi birambuye ku buryo bwo kwiga, bityo, babimenyeshejwe babonye uruhushya kuri buri somo.Inzira zose zubushakashatsi zakozwe hakurikijwe amabwiriza n’amategeko abigenga mu Itangazo rya Helsinki.
Mbere yo gutangira gukuramo inzoga, abarwayi 20 batoranijwe kandi batabishaka bahabwa itsinda A cyangwa itsinda B (10 muri buri tsinda) kugirango bavure lazeri nkeya.Kwemeza byakozwe hakoreshejwe uburyo bworoshye bwo gutoranya hamwe no kugabana 1: 1.Hateguwe agasanduku karimo impapuro makumyabiri zuzuyemo impapuro, icumi muri zo zanditsweho amagambo "Itsinda A" andi icumi yanditseho "Itsinda B".Buri wese mu bitabiriye amahugurwa yasabwe guhitamo urupapuro rwiziritse mu gasanduku hanyuma akaruha imwe mu matsinda abiri akurikije.Uburyo bumwe bwongeye gusubirwamo muri buri tsinda, byerekana uruhande rumwe rwikigero kinini nka "ikizamini" naho urundi ruhande nka "kugenzura" muburyo bwo gutandukanya umunwa.
Usibye inyandiko zisanzwe za ortodontique (amafoto yimbere nayandi adasanzwe, amafoto, hamwe n amenyo yerekana amenyo), amasomo yateguwe kugirango avurwe neza, yanditswe mugukora amateka yubuvuzi n amenyo.Abarwayi basabwe kandi gukora isuku yuzuye yo mu kanwa no kuyogoza hakurikiraho amabwiriza mu isuku ikwiye yo mu kanwa (gukoresha uburoso bw'amenyo, indabyo hamwe no gukaraba hagati).
Gukosora Maxillary na mandibular hamwe nibikoresho bigororotse Roth ibikoresho (Mini 2000; Ormco, USA) hamwe na 0.022 ″ \ (\ x) 0.028 ″ ibibanza byakosowe mubarwayi bose binjijwe mu gisirikare, aho uburyo bwo gukosora bwashyizwe mu matsinda yombi kandi bugenwa n’umukoresha umwe..Nyuma yaho, umurwayi yoherejwe gukuramo primaire ya maxillary kugirango yemere umwanya uhagije kugirango sock ikire nyuma yo kuyikuramo mbere yo gutangira kuyikuramo nyuma y'amezi 2 nyuma yo kuyakuramo.Guhuza noneho biratangira kandi guhuza byuzuye mugihe 0.016 ″ x 0.022 wire insinga zicyuma zidashobora kwinjizwa mumenyo yose ya maxillary.
Mbere yo gutangira gukuramo inzoga, hejuru ya kabiri ya premolars hamwe na molars ya mbere byahujwe hamwe na 0.009-inimero-umunani-shusho-umunani ku mpande zigerageza no kugenzura ayo matsinda yombi.Mubyongeyeho, ibibyimba byinshi byahujwe hamwe kimwe nigice cyinyuma kugirango bifashe guhagarara no gukumira gutandukana kwabo.
Gukuramo Canine mu matsinda A na B byakozwe hakoreshejwe nikel-titanium (NiTi) ifunze amasoko ya coil (Ormco, Amerika), haba ku mpande zigeragezwa no kugenzura, irambuye hagati y’ibifuniko by’imigozi ya kine hamwe n’ibifata ku muyoboro wa mara, hamwe n’imbaraga za g 150 zapimwe dinometero (Morelli, Berezile).
Lazeri ya diode (Wiser; Muganga Smile-Lambda Spa, Brendol, Ubutaliyani) yakoreshejwe nka lazeri nkeya, itanga imirasire yimirasire ifite uburebure bwa 980 nm nimbaraga zisohoka mW 100 muburyo bukomeza.Fibre yindege (AB 2799; Muganga Smile-Lambda Spa, Brendola, Ubutaliyani) yakoreshejwe mugukwirakwiza ikibanza cya cm2 hamwe nigitereko cyo hejuru, gishyira hejuru ya fibre kumurongo wa maxillary hagati ya gatatu ya maxilla.umuzi wa kine kuruhande rwubushakashatsi (ukurikije amabwiriza yabakozwe, byibuze cm 1.5 mugihe utitaye) kumasegonda 8 (Ishusho 1).Ubwinshi bwingufu zikoreshwa kuri buri gice cyari 8 J / cm2 (1 J / cm2 kumasegonda).Ibipimo bya laser byakoreshejwe bigaragara mu mbonerahamwe ya 1. Hafashwe ingamba mbere yo gukoresha laser, kandi umurwayi nuwayikoresheje bakoresheje amadarubindi yatanzwe nuwabikoze, bitewe nuburebure bwakoreshejwe.
Fibre ya fibre yafashwe intera ya cm 1.5 uvuye mumuzi ya kine ya maxillary kuruhande rwubushakashatsi ukurikije amabwiriza yabakozwe.
Tekinike yo gucamo umunwa yakoreshejwe mumatsinda yombi, kandi buri wese mu bitabiriye amahugurwa yatoranijwe kugirango yakire LILI kuruhande rumwe rwikariso ya maxillary no kurundi ruhande nkigenzura.Mu itsinda A, amasomo yakiriye LILT kumunsi 0, 3, 7, 14 hanyuma buri byumweru 2, mugihe mumatsinda B yakoreshwaga buri byumweru 3 kuruhande rwubushakashatsi mugihe cyose cyo kwiga (ibyumweru 12) bya LILT.Urumuri rwa lazeri narwo rwashyizwe muburyo bworoshye kuruhande rwigenzura ryamatsinda yombi, rutanga umwanya wa platbo murwego rwo guhuma abarwayi banditswe.Bitewe nimiterere yo gutabara muriki cyiciro, uyikoresha ntashobora gushukwa.
Mbere yo gukusanya ingero, impande zombi za kine nini zahanaguweho ipamba, zihererana hamwe na retraktor yonyine, guswera, hamwe nudupapuro twa pamba, hanyuma buhoro buhoro byumishwa kuri s 5.Ingero zavanywe mu bice bya kure bya kine nini cyane ukoresheje impapuro zisanzwe zungurura (Whatman, Maidstone, UK) hanyuma zicibwa mu bunini busanzwe bwa 2 × 10 mm2.Ongera witonze buri murongo mu cyuho kugeza igihe wunvise ukurwanya gake, hanyuma ubirekere mumasegonda 60 mugihe ukomeje gufunga neza (Ishusho 2).Nyuma yo gukuraho, imirongo mishya yashyizwe buri min 1 kugirango ibone imirongo 4 kuri buri mwanya.Hafashwe kandi ingamba zo kwirinda kwangirika kwa mashini kwangirika kwa gingival.Kujugunya ingero zanduye n'amacandwe cyangwa amaraso hanyuma ukusanyirize hamwe.Ingero za GCF zafashwe ku murongo fatizo (mbere yuko itangira rya kineine), uhereye ku bice bya kure bya kine mu matsinda A na B, ku mpande zigerageza no kugenzura, usibye iminsi 7, 14, na 21.
Kugabanya ibitekerezo (Ca37; Cavex, Haarlem, Ubuholandi) byakozwe mbere yo gukuramo inzoga kandi byagarutsweho buri byumweru 3 mugihe cyo kwiga ibyumweru 12 kuri buri ruzinduko.Muri buri ruzinduko, hakuweho insinga hamwe na coil, hafatwa alginate, hanyuma barabara.Ubwoko bw'amenyo noneho butondekwa kandi bugashyirwaho izina ryumurwayi, umubare nitariki.Icyitegererezo cya plaster cyarasuzumwe (muri Eos X5 CAD / CAM ya laboratoire ya laboratoire; Dentsply Sirona, PA, USA) kugirango habeho ishusho yibice bitatu (3D) byerekana ishusho yinyo yinyo.Ibipimo nkenerwa byakozwe hifashishijwe verisiyo ya AutoCAD 2013 (AutoCAD; Autodesk, USA).Abaganga b’amavuriro ntibari bazi impande zubushakashatsi nubugenzuzi mugihe cyo gupimwa kugirango birinde kubogama bidafite ishingiro, kandi igenzura ryizewe hagati yiperereza ryakozwe hifashishijwe ibipimo byinshi byakozwe numukoresha umwe nyuma yicyumweru kugirango barebe amakosa yo gupimwa.Ikigereranyo cyo gupima ikigereranyo ni 6%.
Ibintu byinshi byaranze ibimenyetso byabonetse ku menyo y’amenyo, harimo suture yo hagati ya palatal, ingingo ya medialmost yibice byibumoso niburyo bwa gatatu, hamwe nigitereko cyibumoso na iburyo.Umurongo uhagaritse uva kumurongo wo hagati wibumoso n iburyo bwa gatatu hamwe nigituntu cyibumoso na iburyo bwa maxillary kine kugeza kuri suture ya median palatine.Ibipimo by'imbere-inyuma byafashwe hagati y'umurongo wa kineine n'umurongo wa gatatu wikurikiranya kugirango usuzume ibinini (Isanamu 3, 4).
Shakisha ibimenyetso byerekana amashusho yabigenewe yerekana amenyo kugirango bapime inyuma.(Umwe).Suture yo hagati.(b, d).Igituntu cyibumoso na iburyo bwa kineine.(c, e).Imirongo ijyanye nimpera yimbere yimbere ya gatatu ibumoso niburyo bwiburyo.
Nyuma yo gukurwa mu mwobo wa gingival, amatsinda yimpapuro enye zungurura impapuro zegeranijwe ahantu hamwe zashyizwe mumiyoboro ya Eppendorf (Capp, Danimarike) irimo 100 µl ya saline-fosiferi.Imiyoboro ya Eppendorf yarafunzwe kandi irashyirwaho ikimenyetso hanyuma ingero zihita zishyirwa hagati ya 3000 rpm kuminota 10 ukoresheje centrifuge (Hettich Universal 320R BC-HTX320; GMI, MN, USA) kugirango bakure ingero za GCF kumurongo.Imiyoboro ya Eppendorf yabitswe kuri -20 ° C kugeza isesengura ryibinyabuzima.Isesengura ryurwego rwa IL-1β ryakozwe hakoreshejwe enzyme ihuza immunosorbent (ELISA; Cloud-Clone, Howe, USA).Ubwinshi bwa IL-1β bwagenwe no kugereranya ubwinshi bwa optique (OD) bwurugero rwabonetse hamwe nu murongo usanzwe hanyuma ubara ikigereranyo cyo kugereranya umurongo ugaruka kumurongo usanzwe.Hanyuma, ibisubizo kurwego rwa IL-1β bitangwa muri pg / ml / 60 s25.Igishushanyo mbonera cyubushakashatsi cyerekanwe mubishusho 5, byerekana muri make uburyo bwo kwiga.
Isesengura mibare ryakozwe hifashishijwe IBM SPSS kuri Windows verisiyo ya 23.0 (IBM; Armonk, NY, USA).Impinduka zose zingana zari zisanzwe zikwirakwizwa kandi bivuze, gutandukana bisanzwe (SD) na 95% intera intera (CI) byabazwe kandi hakoreshwa ibizamini bya parametric.Impinduka zingana (gukuramo canine no kurwego rwa IL-1β) zagereranijwe hagati yitsinda ryombi ryifashishije icyitegererezo cyigenga cya t-test, mugihe kugereranya hagati ya laser nimpande zigenzura muri buri tsinda byakozwe hakoreshejwe t-test zombi.Gusubiza inyuma imbwa hamwe na IL-1β mu bihe bitandukanye muri buri tsinda byagereranijwe ukwe ukoresheje ingamba zisubirwamo zisesengura itandukaniro hanyuma hagereranywa inshuro ebyiri ukoresheje Bonferroni-yahinduwe urwego rwingenzi. Akamaro kashyizweho kuri p agaciro <0.05. Akamaro kashyizweho kuri p agaciro <0.05. Значимость б кон установлена ​​при значении p <0,05. Akamaro kashyizweho kuri p agaciro <0.05.显 着 性 设定 为 p 值 <0.05。显 着 性 设定 为 p 值 <0.05。 Значимость б кон установлена ​​на оровне p <0,05. Akamaro kashyizweho kuri p <0.05.
Mugihe cyamasomo, nta somo ryataye haba mugihe cyabanjirije gutabara cyangwa mugihe gisigaye cyubushakashatsi.Amasomo 20 yose yabanje kwinjizwa yarangije igihe cyicyumweru 12 cyo kwiga (amasomo 10 kumatsinda).Urujya n'uruza rw'abarwayi kubigeragezo byose byerekanwe ku gishushanyo cya 6 ukoresheje ibicapo bya CONSORT.Imibare y’imibare y’amasomo yanditswe mu matsinda A na B igaragara mu mbonerahamwe ya 2. Nta kibazo cyo gusenyuka mu ngero z’ubushakashatsi, zakozwe buri byumweru bitatu kugira ngo bapime inyuma.Mubyongeyeho, ibyakiriwe byose bya GCM byakozwe neza kandi birasesengurwa.
Ingano yo gukuramo inzoga nyinshi mu bihe bitandukanye byasobanuwe mu mbonerahamwe ya 3, yerekeye amatsinda yombi A na B. Mu itsinda A, intera nini cyane (± SD) yagenze na kine ya maxillary yavuzwe mu cyumweru cya 3 ko ari mm 1,18 (± 0.04) mm ku ruhande rwa laser, na 0,85 (± 0.04) mm ku ruhande rw’ubugenzuzi, kandi itandukaniro riri hagati yaryo rikaba rifite imibare (p <0.001). Ingano yo gukuramo inzoga nyinshi mu bihe bitandukanye byasobanuwe mu mbonerahamwe ya 3, yerekeye amatsinda yombi A na B. Mu itsinda A, intera nini cyane (± SD) yagenze na kine ya maxillary yavuzwe mu cyumweru cya 3 ko ari mm 1,18 (± 0.04) mm ku ruhande rwa laser, na 0,85 (± 0.04) mm ku ruhande rw’ubugenzuzi, kandi itandukaniro riri hagati yaryo rikaba rifite imibare (p <0.001). Величина ретракции верхнечюстного клыка в разные мом план времени описана в бале 3 для обеих группасы А һәм В.В группе А наибольшее среднее расстояние (± SD), пройденное верхнечюстным кманом на 3-й неделе, соверляет 1,18 (± 0,04) m на стороне лазера и 0,85 (± 0,04) m на стороне ки 1). Ingano yo gukuramo kine ya maxillary kumwanya utandukanye yasobanuwe mumbonerahamwe 3 kumatsinda yombi A na B. Mu itsinda A, intera ndende ndende (± SD) yagenze na kine ya maxillary ku cyumweru cya 3 ni 1.18 (± 0.04) mm kuruhande rwa laser na 0,85 (± 0.04) mm kuruhande rwigenzura, mugihe itandukaniro riri hagati yaryo rifite imibare (p <0.001).Ku matsinda A na B, urwego rwa maxillary canine retraction kumwanya utandukanye rwasobanuwe mumbonerahamwe 3.在 A 组 中 ， 上颌 尖牙 移动 的 最大 ± (± SD) 在 第 3 周 报告 为 激光 侧 18 1.18 (± 0.04) mm ， 对照 侧 为 0.85 (± 0.04) mm ， 两者 之间 的 差异 具有 统计学 意义 <p <0.001）。18 a 组 中 ， 上 颌 移动 的 最 第 距离 18 18 18 18 18 18 18 18 18 18 18具有 具有 具有 具有 具有 具有 具有 <<p <0.001）。 В группе А барноно среднее расстояние (± SD) ماتжения кжов верхнейюсти на 3-й неделе совирило 1,18 (± 0,04) mill на стороне лазера и 0,85 (± 0,04) m н стороне кля, зазя Mu itsinda A, intera ntarengwa isobanura (± SD) yimodoka ya kine nini cyane mucyumweru cya 3 yari 1,18 (± 0.04) mm kuruhande rwa laser na 0,85 (± 0.04) mm kuruhande rwigenzura, itandukaniro riri hagati yabyo ryari rifite imibare (p <0.001). Nyamara, ingano yo kugenda yinyo yagabanutse mucyumweru cya 6 kumpande zombi no kugenzura, hanyuma igenda yiyongera buhoro buhoro nyuma yicyumweru cya 9 nicya 12, ubwinshi bwimyanya yinyo iba hejuru cyane kuruhande rwa lazeri ugereranije nuruhande rugenzura (p <0.001), kumwanya wigihe cyose. Nyamara, ingano yo kugenda yinyo yagabanutse mucyumweru cya 6 kumpande zombi no kugenzura, hanyuma igenda yiyongera buhoro buhoro nyuma yicyumweru cya 9 nicya 12, ubwinshi bwimyanya yinyo iba hejuru cyane kuruhande rwa lazeri ugereranije nuruhande rugenzura (p <0.001), kumwanya wigihe cyose.Nyamara, umubare ntarengwa wo kwimura amenyo wagabanutse ku cyumweru cya 6 ku mpande zombi za laser no kugenzura, hanyuma ugenda wiyongera buhoro buhoro mu byumweru 9 na 12, hamwe n’ubwinshi bwo kwimura amenyo hejuru cyane kuruhande rwa laser.laser ugereranije nitsinda rishinzwe kugenzura.стороны (p <0,001) восе мом план времени. ruhande (p <0.001) igihe cyose.然而 ， 激光 侧 和 侧 的 平均 6 周 下降 ， 第 第 周 周 第 第 第 周然而 ， 激光 侧 和 侧 的 第 6 周 下降 ， 第 第 第 第 第 第 第 第 < Однако среднее количестинг мжений зубов на стороне лазера и ннн стороне уменьшилось на 6-й неделе, а затем постепенно увеличилось через 9 и 12 недель, а количевс во с с с с с е с стороной (p <0,001) во мом план времени. Nyamara, umubare ugereranije winyo yinyo kuruhande rwa laser no kuruhande rwo kugenzura wagabanutse mucyumweru cya 6 hanyuma buhoro buhoro wiyongera nyuma yibyumweru 9 na 12, kandi umubare winyo yinyo kuruhande rwa laser wari mwinshi cyane ugereranije kuruhande (p <0.001) kumwanya wose mugihe. Umubare wuzuye w amenyo (± SD) mugihe cyibyumweru 12 byo kwiga wari hejuru cyane kuruhande rwa laser hamwe na mm 4.45 (± 0.13), ugereranije nu ruhande rwigenzura rwari mm 3.16 (± 0.14) mm (p <0.001). Umubare wuzuye w amenyo (± SD) mugihe cyibyumweru 12 byo kwiga wari hejuru cyane kuruhande rwa laser hamwe na mm 4.45 (± 0.13), ugereranije nu ruhande rwigenzura rwari mm 3.16 (± 0.14) mm (p <0.001). Общая величина смещения зубов (± SD) за 12-недельный период исследования б бар значительно вше на стороне лазера - 4,45 (± 0,13) мим по сравнению с снной стороной, которая со ±ляя 3,16. Umubare wuzuye wo kwimura amenyo (± SD) mugihe cyibyumweru 12 byo kwiga wari hejuru cyane kuruhande rwa lazeri, mm 4.45 (± 0.13) mm, ugereranije no kugenzura, wari mm 3.16 (± 0.14) mm (p <0.001).在 为期 12 周 的 研究 期间 ， 激光 ± 牙齿 牙齿 移动 (± SD)在 为期 12 周 的 研究 期间 ， 激光 侧 牙齿 ± ± 总量 ± ± (± SD) В течение 12-недельного периода исследования общее перемещение зубов (± SD) было значительно вше на стороне лазера и соверляло 4,45 (± 0,13) mir по сравнению с 3,16 (± 0,14) Mugihe cyibyumweru 12 byo kwiga, amenyo yose (± SD) yari hejuru cyane kuruhande rwa laser kuri mm 4.45 (± 0.13) ugereranije na 3.16 (± 0.14) mm mumatsinda yo kugenzura (p <0.001).
Mu itsinda B, icyitegererezo gisa nicyerekanwe mu itsinda A cyakurikijwe, hamwe n’agaciro gakomeye cyane ko kugenda amenyo yandikwa kuruhande rwa laser, ugereranije nuruhande rwigenzura kumwanya wose (p <0.001). Mu itsinda B, icyitegererezo gisa nicyerekanwe mu itsinda A cyakurikijwe, hamwe n’agaciro gakomeye cyane ko kugenda amenyo yandikwa kuruhande rwa laser, ugereranije nuruhande rwigenzura kumwanya wose (p <0.001). В группе Б наблюдалась ан аначичная карина, продемонстриров тая в группе А, со значительно более всок гим значениями мжжения зубов, марег мирированными на стороне лазера, по сравнению с снной стороной во все Itsinda B ryerekanye ishusho isa nitsinda A, hamwe nigiciro kinini cyo kugendana amenyo yanditswe kuruhande rwa laser ugereranije no kugenzura kumwanya wose (p <0.001).在 B 组 中 ， 遵循 与 A 组 相似 的 模式 与 与 时间 点 <<<<<<<<<< <0.00 В группе B, по аналогии с группой A, зарег стированные значения перемещения зубов были значительно выше на стороне лазера по сравнению с чинной стороной во все мом времени (p <0,001). Mu itsinda B, risa nitsinda A, indangagaciro zanditswemo zo kugenda amenyo zari hejuru cyane kuruhande rwa laser ugereranije no kugenzura kumwanya wose (p <0.001).Nyuma yibyumweru 3, urugendo runini rwinyo (± SD) rwanditsweho agaciro ka mm 1,14 (± 0.04) mm kuruhande rwa laser na 0.87 (± 0.03) mm kuruhande.Kugenda kumenyo kwagabanutse nyuma yicyumweru cya 6 hanyuma byiyongera buhoro buhoro. Umubare wuzuye wo gukuramo inzoga (± SD) mugihe cyibyumweru 12 byo kwiga kumpande ya laser no kugenzura, wari mm 4.35 (± 0.12) mm, na 3.10 (± 0.06) mm, kandi itandukaniro ryabo ryari rifite imibare ikomeye (p <0.001). Umubare wuzuye wo gukuramo inzoga (± SD) mugihe cyibyumweru 12 byo kwiga kumpande ya laser no kugenzura, wari mm 4.35 (± 0.12) mm, na 3.10 (± 0.06) mm, kandi itandukaniro ryabo ryari rifite imibare ikomeye (p <0.001).Igiteranyo cyo gukuramo inzoga (± SD) mugihe cyibyumweru 12 byo kwiga kuri lazeri no kugenzura byari mm 4.35 (± 0.12) mm na 3,10 (± 0.06) mm, kandi itandukaniro ryabyo ryari rifite imibare ikomeye.(р <0,001). (p <0.001).在 为期 12 周 的 研究 期间 ， 激光 侧 ± ± ± ± ± ± (± SD)在 为期 12 周 的 研究 ， 激光 侧 和 ± ± ± ± ± ± (± sd) В течение 12-недельного периода исследования общая (± SD) ретракция клыка на стороне лазера и мнной стороне составила 4,35 (± 0,12) mir и 3,10 (± 0,06) mm соответственно, и разница б б Mugihe cyibyumweru 12 byo kwiga, igiteranyo (± SD) cyo gukuramo urumogi kuruhande rwa laser no kuruhande rwarwo rwari mm 4.35 (± 0.12) mm na 3,10 (± 0.06) mm, kandi itandukaniro ryari rifite imibare (p <0.001). .Imbonerahamwe 4 isobanura kugereranya urwego rwo gukuramo kine kumwanya utandukanye hagati ya lazeri no kugenzura kuruhande muri buri tsinda ryiga.
Nubwo urwego rwo gukuramo kine na laser rwarushijeho kuba mu itsinda A kuruta mu itsinda B igihe cyose, iri tandukaniro ntiryigeze rifatwa nk’imibare ugereranije nitsinda B (p = 0.08-0.55).Kubijyanye no kwiyongera kw'ijanisha (± SD) mugukuramo kine yagezweho na buri protocole, protocole yakoreshejwe mumatsinda A yiyongereyeho 40,78 (± 4.81)%, mugihe protocole yakoreshejwe mumatsinda A yiyongereyeho 40 .22 (± 4.80)% mumatsinda B. protocole ya progaramu ya laser yakiriwe.Nyamara, nubwo iyi ijanisha ryari hejuru cyane mumatsinda A ugereranije nitsinda B, itandukaniro riri hagati yabo ntabwo ryari rifite imibare (p = 0.82).Byongeye kandi, byagaragaye ko imiterere yimikorere y amenyo mumatsinda yombi asa nkaho (Ishusho 7).
Gukuramo lazeri ya kineine (mm) kumwanya utandukanye mumatsinda yombi yo kwiga mugihe cyibyumweru 12 byo kwiga.
Imbonerahamwe 5 isobanura urwego rwa IL-1β mu matsinda A na B ku bihe byose byapimwe kuri laser no kuruhande.Mu itsinda A, itandukaniro riri hagati yuruhande rwa laser no kugenzura kuruhande rwibanze ntabwo ryari rifite agaciro kubiciro bya IL-1β (p = 0.56). Urwego rwo hejuru rwa IL-1β (± SD) rwanditswe kumunsi wa 7 kumpande zombi za laser no kugenzura, hamwe nagaciro ka 0.152 (± 0.004) pg / ml / 60 s, na 0.127 (± 0.004) pg / ml / 60 s, kandi itandukaniro ryabo ryari rifite imibare ikomeye (p <0.001). Urwego rwo hejuru rwa IL-1β (± SD) rwanditswe kumunsi wa 7 kumpande zombi za laser no kugenzura, hamwe nagaciro ka 0.152 (± 0.004) pg / ml / 60 s, na 0.127 (± 0.004) pg / ml / 60 s, kandi itandukaniro ryabo ryari rifite imibare ikomeye (p <0.001).Urwego rwo hejuru rwa IL-1β (± SD) rwanditswe kumunsi wa 7 kumpande zombi no kugenzura bifite agaciro ka 0.152 (± 0.004) pg / mL / 60 s na 0.127 (± 0.004) pg / mL./ 60 с соответственно, а разница между ними б кон статистически значимой (p <0,001). / 60 s, kimwe, kandi itandukaniro riri hagati yaryo ryari rifite imibare (p <0.001).在 第 7 天 ， 激光 侧 和 对照 均 记录 记录 到 最高 的 IL-1β (± SD) ， 值为 0.152 (± 0.004) pg / ml / 60 s 和 0.127 (± 0.004) pg / ml / 60 s在 第 7 天 ， 激光 侧 和 对照 均 记录 到 到 水平 的 IL-1β (± SD) ， 值为 0.152 (± 0.004) pg / ml / 60 s 和 0.127 (± 0.004) pg / ml / 6 p <0.001）。Ku munsi wa 7, urwego rwo hejuru rwa IL-1β (± SD) rwanditswe ku mpande zombi za laser no kugenzura bifite agaciro ka 0.152 (± 0.004) pg / mL / 60 s na 0.127 (± 0.004) pg / mL./ 60 s.Разница между ним б кон статистически значимой (p <0,001). Itandukaniro hagati yabo ryari rifite imibare ikomeye (p <0.001). Kugabanuka gahoro gahoro kurwego rwa IL-1β byavuzwe nyuma, kumunsi wa 14 na 21, kumpande zombi za laser no kugenzura, hamwe nagaciro kuruhande rwa laser kari hejuru cyane ugereranije no kuruhande (p <0.001). Kugabanuka gahoro gahoro kurwego rwa IL-1β byavuzwe nyuma, kumunsi wa 14 na 21, kumpande zombi za laser no kugenzura, hamwe nagaciro kuruhande rwa laser kari hejuru cyane ugereranije no kuruhande (p <0.001). После этого сообщалось о постепенном снижении оровней IL-1β на 14 и 21 день как на стороне лазера, так и на стороне нарля, при этом значения на стороне лазера были значительно вще, че зе Nyuma yibyo, kugabanuka gahoro gahoro kurwego rwa IL-1β byavuzwe kumunsi wa 14 na 21 kumpande zombi no kugenzura, hamwe nagaciro kuruhande rwa laser kari hejuru cyane ugereranije no kuruhande (p <0.001). .此后 ， 在 第 14 天和 第 21 天 ， 激光 和 对照 的 的 IL-1β 水平 逐渐 下降 ， 激光 侧 的 值 p p p p (p <0.001)。此后 ， 在 第 14 天和 第 21 天 ， 激光 和 对照 的 的 IL-1β 水平 逐渐 下降 ， 激光 的 的 显 显 着 高于 值 值 ( После этого на 14-й и 21-й дни оровни ИЛ-1β постепенно снижались на стороне лазера и в члеле, при эом значения на стороне лазера были значительно вше, чем на стороне кля (p <0,001). Nyuma yibyo, kumunsi wa 14 na 21, urwego rwa IL-1β rwagabanutse buhoro buhoro kuruhande rwa laser no kugenzura, mugihe indangagaciro kuruhande rwa laser zari hejuru cyane ugereranije no kugenzura (p <0.001).
Mu itsinda B, uburyo busa bwagaragaye mu itsinda A ku bijyanye n’urwego rwa IL-1β, hamwe n’itandukaniro rito ryagaragaye ku murongo fatizo hagati ya lazeri no kugenzura (p = 0.02). Nyuma yiminsi 7, impinga yurwego rwa IL-1β (± SD) yageze kumpande zombi, hamwe na 0.139 (± 0.004) pg / ml / 60 s kuruhande rwa laser, na 0.122 (± 0.003) pg / ml / 60 s kuruhande rwigenzura, hamwe nagaciro kuruhande rwa laser bifatwa nkurwego rwo hejuru (p <0.001). Nyuma yiminsi 7, impinga yurwego rwa IL-1β (± SD) yageze kumpande zombi, hamwe na 0.139 (± 0.004) pg / ml / 60 s kuruhande rwa laser, na 0.122 (± 0.003) pg / ml / 60 s kuruhande rwigenzura, hamwe nagaciro kuruhande rwa laser bifatwa nkurwego rwo hejuru (p <0.001).Nyuma yiminsi 7, urwego rwo hejuru rwa IL-1β (iation gutandukana bisanzwe) rwageze kumpande zombi: 0.139 (± 0.004) pg / ml / 60 s kuruhande rwa laser na 0.122 (± 0.003) pg / ml / 60 s.на чнной стороне, при этом значения на стороне лазера считались статистически более высок уми (p <0,001). kuruhande rwigenzura, mugihe indangagaciro kuruhande rwa laser zafatwaga nkurwego rwo hejuru (p <0.001). 7 天后 ， 两侧 达到 IL-1β 水平 峰值 （± SD） ， 激光 侧 0.139 （± 0.004） pg / ml / 60 s ， 激光 侧 为 0.122 （± 0.003） pg / ml / 60 s 在 控制 侧 ， 激光 7 天 后 ， 两 侧 达到 il-1β 水平 （（±） ， 激光 侧 为 为 13 0.139 （± 0.004） pg / ml / 60 S ， 侧 为 0.122 （ <， ， 侧 的 值 在 统计 <<p <0.001）。Nyuma yiminsi 7, urwego rwo hejuru rwa IL-1β (± SD) rwagezweho kumpande zombi: 0.139 (± 0.004) pg / ml / 60 s kuruhande rwa laser na 0.122 (± 0.003) pg / ml / 60 s kuruhande rwigenzura., лазер Значения на стороне были статистически выше (p <0,001). , laser Indangagaciro kuri buri ruhande zari hejuru cyane (p <0.001).Urwego rwa IL-1β rwaragabanutse buhoro buhoro kumpande zombi kumunsi wa 14 na 21, kandi urwego rwanditswe kuruhande rwa laser rwari hejuru cyane ugereranije no kugenzura kumwanya wigihe (p = 0.001-0.002).Kugereranya urwego rwa IL-1β kumwanya utandukanye hagati yuruhande rwa laser nu ruhande rwo kugenzura muri buri tsinda ryiga ryasobanuwe mu mbonerahamwe ya 6.
Iyo ugereranije urwego rwa IL-1β hagati yitsinda ryombi ryiga, itandukaniro ridasanzwe ryanditswe kuruhande rwa laser kuri baseline (p = 0.96). Ku munsi wa 7 nuwa 14, itandukaniro rinini ryibarurishamibare ryanditswe hagati yimpande za laser mumatsinda yombi, hamwe nagaciro gakomeye kaba kuruhande rwa laser mumatsinda A (p <0.001). Ku munsi wa 7 nuwa 14, itandukaniro rinini ryibarurishamibare ryanditswe hagati yimpande za laser mumatsinda yombi, hamwe nagaciro gakomeye kaba kuruhande rwa laser mumatsinda A (p <0.001). Н 7 Ku munsi wa 7 na 14, habaye imibare itandukanye cyane hagati yimpande za laser mumatsinda yombi, hamwe nagaciro gakomeye kerekeranye nimpande za laser mumatsinda A (p <0.001).在 第 7 天和 第 14 天 ， 两组 激光 侧 差异 有 统计学 ， A 组 激光 侧 的 <（p <0.001）。 A Н 7 7 Ku munsi wa 7 na 14, itandukaniro riri hagati yaya matsinda yombi ryari rifite imibare ikomeye kuruhande rwa laser, hamwe nagaciro gakomeye kuruhande rwa laser mumatsinda A (p <0.001).Nyuma yiminsi 21, nta tandukaniro rikomeye ryabaye hagati yaya matsinda yombi (p = 0.26).Urwego rwa IL-1β mu matsinda yombi rwagize imico imwe, rugera ku munsi wa 7 kandi rugabanuka buhoro buhoro ku munsi wa 14 na 21 (Ishusho 8).
Icyari kigamijwe muri ubu bushakashatsi kwari ukugira ngo dusuzume kandi tugereranye ingaruka za LILR ku gukuramo kanseri hakoreshejwe protocole harimo na radiyo yo mu bwoko bwa lazeri nyinshi ku munsi wa 0, 3, 7, 14 na buri byumweru 2 nyuma yaho (Itsinda A) n’abarwayi baherutse kwinjira.habaye kwibutsa bike ugereranije na rejime yakoreshwaga na laser mugihe cyibyumweru 3 (itsinda B).Yaba protocole rusange yumurongo mwinshi 7,13,26 cyangwa protocole yicyumweru 315,17,18, protocole zombi zasobanuwe mubitabo.Hashingiwe ku bisubizo byatanzwe mu bushakashatsi burimo gukorwa, hypothesis null ntiyigeze yangwa, kandi binyuze mu gushyira mu bikorwa protocole ebyiri zize, umubare ungana ugereranije n’imbwa zagezweho.
Igishushanyo mbonera cyubushakashatsi nubuvuzi bwateganijwe (RCT).RCTs ifatwa nkigipimo cya zahabu mugusuzuma ingaruka zo gutabara27.Tekinike yacitsemo umunwa nayo yakoreshejwe, inyungu nyamukuru yabyo nuko ihinduka ryibintu bivanwaho, buri murwayi akora nkumugenzuzi we bwite, bityo bikagabanya umubare wabitabiriye.
Amasomo yose yashyizwe mubushakashatsi yasabwaga gukuramo maxillary ya mbere ya premolar ikurikirwa no gukuramo kine mu rwego rwo kuvura imitekerereze.Kubera ko gukuramo bishobora guhindura igipimo cya RTM mukongera ibikorwa byibimenyetso byerekana umuriro, ibyo nabyo bikaba bishobora guhisha ingaruka za LILT kandi bigatanga ibisomwa byurwego rwa IL-1β mugihe ukoresheje lazeri, kuvura byakorwaga mbere yo kuvurwa, bitanga igisubizo cyiza.Gukiza sock yo gukuramo igisubizo itanga igihe gihagije kandi ikanesha ingaruka ziterwa no kwihuta kwakarere28.Uku kwirinda kandi kwarafashwe n’abanditsi bamwe, 11 bakoze ubushakashatsi ku ngaruka za LILT ku gipimo cya OTM mu gihe cyo gukuramo imbwa bapima urugero rwa biomarkers nka IL-1β no guhindura ibintu bikura β1 (TGF-β1) muri GCF.
Ubwoko bwa lazeri yakoreshejwe muri ubu bushakashatsi yari laser ya diode semiconductor yakoreshejwe kuri 980 nm ukurikije ibyifuzo byabayikoze kugirango biostimulation nziza.Ibi birashobora gusobanurwa nuko uburebure bwa lazeri (650-1200 nm), niko inyama zinjira cyane29.Nyamara, ubu burebure bwasabwe bwakoreshejwe mubundi bushakashatsi bwinshi, butanga ingaruka nziza yihuta ya 8.30 ningaruka mbi za 14.
Ikindi kintu cyingenzi kigira ingaruka kumikorere ya LILI no kuvura biostimulation ni urugero cyangwa ubwinshi bwingufu.Iyo usuzumye ibitabo, wasangaga hariho itandukaniro rinini muri dosiye yingufu za LILI kugirango yihutishe GTM.Bamwe mu banditsi bavuga ibisubizo byiza iyo bakoresheje ingufu nkeya kuva 0.7131, 532.33, 7.514 kugeza 8 J / cm234.35, mu gihe abandi bashakashatsi nabo bavuga ingaruka za LILR ku gipimo cya GTM ku bwinshi bw’ingufu, urugero, 25 J / cm2.cm27.36.Mubikorwa byubu, igipimo cyingufu za lazeri zo hasi ya 8 J / cm2 cyatanzwe no guhura rimwe kumuzi ya kine ya maxillary kumasegonda 8 ukoresheje inama yo hejuru kugirango ugabanye ikibanza cya cm 1.Hariho isano ritaziguye hagati yubunini bwa beam nuburebure bwa laser, nabwo bukaba bufite ishingiro bwo gukoresha ibihangano byo hejuru hejuru muri ubu bushakashatsi29,37.Porogaramu imwe imwe ya protocole hamwe nubunini bunini bwa beam ikorwa hamwe no guhuza no guhuza 8 hamwe no gukuramo kine 38.
IL-1β izwiho kuba ari cytokine yingenzi itera intangiriro ya OTM kandi ifatwa nkikimenyetso cyo gufata amagufwa.Kubwibyo, urwego rwa IL-1β rwasuzumwe na laser mubushakashatsi bwinshi11,39,40 kugirango bagerageze kumenya isano ryabo.Mu iburanisha ririho ubu, urwego rwa IL-1β muri GCF rwasuzumwe ku mpande zigerageza no kugenzura buri tsinda hakoreshejwe uburyo bubiri butandukanye bwa LILI ku minsi 0, 7, 14, na 21.
Muri ubu bushakashatsi, gukuramo kanseri na lazeri mu matsinda A na B byari hejuru cyane ugereranije no mu itsinda rishinzwe kugenzura ibihe byose byasuzumwe, bigera ku cyumweru cya 3, bikagabanuka icyumweru kimwe mu cyumweru cya 6, hanyuma bigenda byiyongera kugeza ku cyumweru cya 12..Urugendo rwa kine rwerekanwe mucyumweru cya 3 rushobora gusobanurwa ningaruka zo kwimura amenyo yambere, harimo: kwimura imizi muri PDL, ubumuga bwamagufwa bitewe no guhindagurika no kunyerera, hamwe nigitutu cyo kwikuramo iryinyo bitewe nubushake bwa sock sock Indege ya 41. Byongeye kandi, byagaragaye ko inzira yibinyabuzima ikora yihuta mugihe igufwa rigumye mumwanya uhindagurika.Gutinda gukurikiraho kugaragara hagati yibyumweru 3 na 6, birashoboka bitewe nigihe cyo gutinda gishobora gutandukana kuva ibyumweru 2 kugeza 10, ni igihe cyo guhungabana kwa PDL gisubiramo kandi kigakuraho amagufwa yegeranye n’ahantu hajanjaguwe, bigatuma amagufwa agenda.amenyo.Ikindi kintu kigira uruhare muri uku kwitegereza gishobora kuba ari uko fibre ogisijeni, fibre ya kolagen, hamwe n'amagufwa ya alveolar ivugurura uruhande rw'impagarara nabyo bishobora kugabanya umuvuduko wo kugenda amenyo.Uburyo nk'ubwo bwo kugenda amenyo bwabonetse mu bushakashatsi bwakozwe 45 ugereranya ingaruka za LILI na corticotomy ku gipimo cyo gufata kine, bagaragaje ko kugenda amenyo byari bikomeye mu byumweru 2 na 5, bikurikirwa no kugabanuka gukabije mu byumweru 2 na 5.icyumweru.Ibi ntabwo byavuzwe kuruhande rwa laser mucyumweru cya 7, ariko ntabwo byavuzwe kuruhande rwa corticotomy.
Bivugwa ko kwiyongera kwijanisha ryintera yimikorere ya kine ya maxillary kuva kuruhande rwa lazeri yari 40.78% mumatsinda A na 40.22% mumatsinda B. Ubwiyongere bugaragara bwimikorere yinyo iherekejwe no gukoresha lazeri irashobora gusobanurwa kurwego rwa selire no kwinjiza ingufu za lazeri hamwe na fotoreceptors mumyanya yubuhumekero ya electron- transport.Izi ngaruka ziganisha kumikorere mugihe gito cyurwego rwubuhumekero, biganisha kuri fosifori ya okiside hamwe nimpinduka muri redox ya mitochondriya selile na cytoplazme.Na none, imbaraga zo gutwara selile ziyongera mukongera itangwa rya ATP.Byongeye kandi, hari kwiyongera mubushobozi bwa mitochondrial membrane, alkalisation ya cytoplazme, hamwe na synthesis ya acide nucleic.Kubera ko ATP izwiho kuba ifaranga ry'ingirabuzimafatizo, LILI igira uruhare mu mikorere isanzwe ya selile ikora ibidukikije byiza byo kugenda amenyo46.Rero, duhereye kubisubizo byacu, dushobora gufata umwanzuro ko gukoresha LILT nkumugereka wubuvuzi bwa ortodontique bishobora kwihutisha OTM tutitaye ko ikoreshwa kenshi nka rejime mumatsinda A (kumunsi 0, 3, 7, 14 na buri munsi).nyuma yiminsi 2) ibyumweru), cyangwa niba ikoreshwa gake mumatsinda B (buri byumweru 3), kubwibyo, hypothesis null ntabwo yanze.
Ingaruka zisa nkiyihuta ya protocole ebyiri zapimwe LILT zavuzwe muri ubu bushakashatsi zishobora guterwa no kuba hari urwego rwimikorere ya selile aho kwiyongera kwimikorere ya selile hamwe no guhura na LILT bibaho muburyo bwambere, ariko hanyuma bikagaragarira kenshi (nko mumatsinda A), bitewe nubuzima bwibinyabuzima bwuzuye ntibizongera gukora cyane.Rero, turashobora kwibwira ko ingaruka za LLLT kurwego rwa selire zidashobora guhuzwa.Kubireba isano iri hagati yurwego rwimbaraga nihuta ryinyo, igitekerezo cya biosaturation cyasobanuwe mbere.
Nyuma yo gusuzuma ubuvanganzo buriho, twagereranije kwiyongera kwa 1.4 (40-41%) muri WTM twabonye mubushakashatsi bwacu dukoresheje protocole ebyiri za laser hamwe nibisubizo bya raporo zindi.Ubushakashatsi bumwe bwerekanye ibisubizo bisa 11,30,48,49 mugihe abandi batangaje ko agaciro gahoro gahoro gahoro gakoreshwa hakoreshejwe LILI7,18,32,40.Ku rundi ruhande, agaciro kihuta cyane kuruta kavuzwe mu bizamini biriho ubu, kuva kuri 1.65 × 17 kugeza kuri 2x OTM15, 34, 39, 50, bishobora kuba bifitanye isano na bamwe muri bo Koresha imikufi yo kwifungisha nta guterana amagambo 15. Iri tandukaniro mu bisubizo byatangajwe mu bitabo rishobora guterwa nuburyo butandukanye bwo gukoresha lazeri, uburebure bw’umuvuduko, imbaraga zerekana, kugereranya intera, n'ibindi..Icyakora, byagaragaye ko ingufu nkeya (urugero 2.5, 5 na 8 J / cm2) zitanga uburyo bwiza bwo kwihuta ugereranije n’ubucucike bukabije, birakwiye ko tumenya ko dosiye yakoreshejwe mubushakashatsi bwacu yari 8 J / cm2.cm2.
Gusobanura urwego rwa IL-1β mugice cya kure (kuruhande rwo kwikuramo) nyuma yo gusesengura ingero za GCF zabonetse zerekanye ubwiyongere bukomeye bwibarurishamibare buva kumurongo (ni ukuvuga impinga) kumunsi wa 7 bikurikirwa no kugabanuka buhoro buhoro kugera kumurongo.ku kibaho A na B, kuruhande rwa laser no kuruhande rwo kugenzura.Ibi birashobora gusobanurwa nuko icyiciro cyambere cya OTM mubisanzwe kijyana no kwiyongera mubikorwa bya osteoclast.IL-1β nayo ifatwa nkibimenyetso byambere byamenyekanye bifitanye isano no gufata amagufwa, kandi imvugo ya IL-1β yavuzwe ko yiyongereye ku mbaraga hanyuma igabanuka mubushakashatsi bwinshi11,20,51.
Mubyongeyeho, urwego rwa IL-1β rwari hejuru kuruhande rwa laser ugereranije nitsinda rishinzwe kugenzura mumatsinda yombi yo kwiga kumwanya wose wapimwe usibye ibyingenzi, kandi hariho itandukaniro rinini mubarurishamibare hagati yabo.Ibi byerekana ko imishwarara ikabije ya lazeri yateje igisubizo cyibinyabuzima mu mitsi ya parontontal kuruhande rwibigeragezo muburyo bwo gukangura imikorere ya osteoclast kuruhande rwacometse mugihe cyo kunyoza amenyo ya ortodontique.Ingaruka za LLLT kurwego rwa IL-1β zerekanwe mubushakashatsi butandukanye11,39,40.
Iyo ugereranije urwego rwa laser-IL-1β mu matsinda yombi y’ubushakashatsi, urwego rwarushijeho kuba rwinshi mu itsinda A ugereranije n’itsinda B ku munsi wa 7 na 14. Ibi birashobora gusobanurwa n’umubare munini w’imirasire ya lazeri mu itsinda A mu gihe cy’iminsi 21 yo kwitegereza, aho imirasire yakozwe ku munsi wa 0, 3, 7, na 14, naho mu itsinda rya B, ku rutonde rwa mbere, ku rutonde rwa A, ariko ku itsinda rya 1, ariko ku itsinda rya 1 ryarashwe ku munsi wa 0. murwego rwo gusubirana imbwa ugereranije kuruhande rwa laser mumatsinda B, kuko nta kamaro k'imibare kari.Mu matsinda A na B, itandukaniro ryavuzwe mugukuramo kine hagati yimpande za laser mubyukuri byavuyemo ubwinshi bwimikorere ya kine.Kubwibyo, turashobora kuvuga ko itandukaniro ryibarurishamibare ridasobanura byanze bikunze akamaro kivuriro.
Ubuvuzi buke bwa lazeri, iyo bukoreshejwe hamwe nibipimo bikoreshwa muri ubu bushakashatsi, birashobora kwihutisha neza kugenda kw amenyo ya ortodontique inshuro zigera kuri 1.4, zaba zikoreshwa mugihe kinini cyangwa gito, bihura no gukurikirana buri gihe, wenda.bikwiriye abarwayi.
Ubwiyongere bwimikorere yinyo ya ortodontique mugihe cya LILI yaherekejwe no kwiyongera kurwego rwa interleukin-1β kuruhande rwafunzwe, ibyo bikaba byerekana ko ikoreshwa rya LILI ritera uburyo bunoze bwo kuvugurura amagufwa.
Imibare ikoreshwa kandi / cyangwa yasesenguwe mubyigisho byubu iraboneka kubanditsi babisabwe babisabye.
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