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Manufar wannan binciken shine a kimanta ƙimar ja da baya na canine don ƙayyadaddun hanyoyin kwantar da iska mai ƙarfi biyu (LLLT), gami da babba da ƙananan mitoci.An raba marasa lafiya 20 bazuwar zuwa ƙungiyoyi biyu.A cikin rukunin A, an bazu ɗaya gefen maxillary baka don karɓar LILT a ranakun 0, 3, 7, 14, da kowane mako 2 bayan haka, yayin da a rukunin B, gefe ɗaya ya karɓi LILT kowane mako 3.A lokacin nazarin makonni 12, ana duba motsin haƙori kowane mako uku daga farkon ja da baya.Bugu da ƙari, an ƙididdige matakan interleukin-1β (IL-1β) a cikin gingival sulcus ruwa. Sakamako ya nuna haɓakar haɓakar haɓakar canine a kan bangarorin laser na ƙungiyoyi A da B, idan aka kwatanta da bangarorin sarrafawa (p <0.05), ba tare da bambance-bambance masu mahimmanci da aka ruwaito tsakanin bangarorin laser a cikin ƙungiyoyin biyu (p = 0.08-0.55). Sakamako ya nuna karuwa mai yawa a cikin raguwa na canine a kan sassan laser na kungiyoyin A da B, idan aka kwatanta da sassan sarrafawa (p <0.05), ba tare da wani bambance-bambance masu mahimmanci da aka ruwaito tsakanin sassan laser a cikin ƙungiyoyi biyu (p = 0.08-0.55). Результаты выявили значительное увеличение увеличение ороной (p <0,05), без существенных различий между сторонами лазера в обеих группах (p = 0,08-0,55). Sakamakon ya nuna wani gagarumin karuwa a cikin saurin raguwa na canine a gefen laser a cikin ƙungiyoyi A da B idan aka kwatanta da gefen kulawa (p <0.05), ba tare da wani bambanci mai mahimmanci tsakanin sassan laser a cikin ƙungiyoyi biyu (p = 0.08-0.55). ).结果显示，与对照组相比，A 组和B显着差异＂ (p = 0.08-0.55)结果 显示 与 对照组 ， 组和 a 组和 b 组 激光侧 犬齿 回 缩率 显着 （（（（（（5之间 显着 差异 （p = 0.08-0.55….. Результаты показали, что по сравнению сконтрольной начительно выше (p <0,05), на стороне лазера не было существенной разницы между двумя группами (p = 0,508). Sakamakon ya nuna cewa, idan aka kwatanta da ƙungiyar kulawa, ƙwayar canine a kan gefen laser a cikin kungiyoyin A da B ya kasance mafi girma (p <0.05), kuma babu wani bambanci mai mahimmanci tsakanin ƙungiyoyi biyu a gefen laser (p = 0.08-0 .55). Hakanan, matakan IL-1β sun kasance mafi girma a bangarorin laser na ƙungiyoyin biyu, idan aka kwatanta da bangarorin sarrafawa (p <0.05). Hakanan, matakan IL-1β sun kasance mafi girma a bangarorin laser na ƙungiyoyin biyu, idan aka kwatanta da bangarorin sarrafawa (p <0.05). Кроме того, уровни IL-1β были значительно выше на стороне лазера в обеих группах по сравнению с сравнению. Bugu da ƙari, matakan IL-1β sun kasance mafi girma a gefen laser a cikin ƙungiyoyi biyu idan aka kwatanta da gefen kulawa (p <0.05).此外，与对照组相比，两组激光侧的IL-1β 水平显着升高（p <0.05）。此外，与对照组相比，两组激光侧的IL-1β 水平显着升高（p <0.05）。 Кроме того, уровни IL-1β были значительно повышены 5). Bugu da ƙari, matakan IL-1β sun haɓaka sosai a gefen laser a cikin ƙungiyoyi biyu idan aka kwatanta da ƙungiyar kulawa (p <0.05).Don haka, LILI ya sami damar haɓaka motsin haƙori yadda ya kamata, ko ana amfani dashi akai-akai ko kuma da wuya, wanda ke da alaƙa da haɓakar amsawar ilimin halitta, wanda ke nunawa a cikin matakan IL-1β a kan matsa lamba.
An gano maganin orthodontic na dogon lokaci (yawanci a kusa da watanni 20-301) don yin mummunar tasiri ga yarda da haƙuri, ban da haɗari kamar tushen resorption2, caries3, enamel decalcification3 da matsalolin lokaci4,5.Sabili da haka, an ba da shawarar hanyoyi da yawa da nufin haɓaka motsin haƙori na orthodontic (OTM), gami da kulawar tiyata da marasa tiyata.Bugu da ƙari, an bincika tasirin haɗakar hanyoyi guda biyu na haɓakawa da kuma tasirin maimaita tsari guda ɗaya akan saurin OTM6.
Ƙananan maganin laser mai ƙarfi (LLLT) ya kasance ɗaya daga cikin hanyoyin da ba na tiyata ba don hanzarta OTM, amma an sami sakamako masu karo da juna a cikin rahotannin tasirinsa a wannan yanki, yayin da aka rubuta sakamako masu kyau7,8 da kuma mummunan9.Ana iya bayyana waɗannan sakamako masu cin karo da juna ta hanyar bambance-bambance a cikin sigogin aikace-aikacen Laser da aka yi amfani da su a cikin kowane binciken, gami da nau'in laser, hanyar aikace-aikacen, tsayin raƙuman ruwa, adadin radiation, da lokacin fallasa, tunda waɗannan sigogi suna da alaƙa kai tsaye da sakamakon asibiti na aikace-aikacen Laser 10.
Dangane da hanyoyin aikace-aikacen, an ba da rahoton ka'idojin isar da hasken laser daban-daban don sauƙaƙe motsin hakori.Ɗaya daga cikin ƙa'idodin da aka fi amfani da shi ya ƙunshi yin amfani da Laser a ranakun 0, 3, 7, 14, 21 da 30, maimaitu iri ɗaya kowane wata, kuma wannan yarjejeniya ta sami karbuwa daga marubuta da yawa11,12.Wasu kuma sun yi amfani da wani madadin tsarin da ke kusa da tsarin da aka bayyana a baya kuma yana daya daga cikin hanyoyin da ake amfani da su sosai, wanda ake amfani da LILI a ranakun 0, 3, 7, 14, sannan kowane kwanaki 15 har zuwa ƙarshen lokacin nazarin.13. Bugu da ƙari, an ba da shawarar yarjejeniya wanda ya haɗa da aikace-aikacen mako-mako na Laser mai ƙarancin ƙarfi a duk tsawon lokacin ja da baya na canine.Koyaya, babban hasara na waɗannan ka'idoji na al'ada shine yawan ƙimar amsawar haƙuri, wanda zai iya zama da wahala ga kowa.Don haka, ana amfani da ka'idojin da ke buƙatar ƙarancin masu ba da haƙuri, misali, gami da LILI sau 8 a wata ko 15, 16, 17, 18 kowane mako 3.
Tun da an san sojojin kothodontic don haifar da gyare-gyaren kashi, haɓakar sauye-sauyen kumburi shine abin da ake bukata don wannan tsari, wanda ke haifar da rashin daidaituwa na hakora19.Bisa ga binciken da yawa, hanya ɗaya don tantance yiwuwar abubuwan da ke faruwa a cikin ligament na lokaci shine don tantance matakin cytokines a cikin gingival sulcus fluid (GCF).Interleukin-1β (IL-1β) cytokine ne mai aiki sosai a cikin metabolism na kashi kuma ana ɗaukarsa ɗaya daga cikin cytokines mafi ƙarfi a farkon nama na lokaci na OTM.Tun da akwai alaƙa tsakanin matakan IL-1β da rayuwa, fusion da kunna osteoclast, IL-1β za a iya la'akari da shi azaman alamar mahimmanci don ƙididdige matakin motsin haƙori na orthodontic, wanda ke da alaƙa da ingancin gyaran gyare-gyare na alveolar24.
Don haka, makasudin bincikenmu shine kimantawa da kwatanta tasirin NILT tare da tsarin da aka saba amfani da su, gami da yawan yawan amfani a ranakun 0, 3, 7, 14, sannan kowane mako 2 idan aka kwatanta da amfani kowane mako 3.Adadin ja da baya a cikin karnuka a yunƙurin rage yawan tunawa da haƙuri.Bugu da ƙari, an kimanta matakan IL-1β a cikin GCF ta amfani da ka'idoji guda biyu.Maganar banza na binciken na yanzu shine cewa babu wani bambanci a cikin abin da ya faru na raguwa na canine tare da LILI ta amfani da ka'idojin gwaji guda biyu.
Binciken ya kasance gwajin gwaji na asibiti da bazuwar tare da ƙungiyoyi guda biyu masu daidaituwa, kowanne yana gwada ka'idar LILI.Kowane rukuni yana ɗaukar ƙirar bakin da aka raba, gefe ɗaya shine ƙungiyar kulawa kuma ɗayan shine rukunin binciken.
Nazarin ya haɗa da marasa lafiya 20 masu shekaru 15 zuwa 20 waɗanda ke buƙatar kawar da maganin warkewa na farkon premolars na muƙamuƙi na sama, sannan kuma ja da baya na canines.Ƙididdigar girman samfurin sun dogara ne akan kuskuren alpha na 5% da ikon nazarin 80%.Wannan lissafin ya dogara ne akan ma'ana da daidaitaccen karkatarwar canine a cikin binciken da Doshi-Mehta da Bhad-Patil7 suka yi amfani da LILI a ranakun 0, 3, 7, 14 da kowane mako 2 bayan haka (Arm A) kuma a cikin karatun Qamruddin et al.wasu A cikin karatun 15, an yi amfani da LILI kowane mako 3 (rukunin B).An sami amincewar ɗabi'a daga Majalisar Da'a na Kwalejin Dentistry, Jami'ar Alexandria, Alexandria, Masar (IRB: 00010556-IORG: 0008839).Adadin kwamitin da'a na rubutun shine 0111-01/2020.An amince da shi Janairu 21, 2020. An yi rajistar gwajin tare da ClinicalTrials.gov a matsayin "Ka'idojin Laser Low Level Biyu don Auna Gudun Janyewa a Karnuka."Lambar rajistar gwaji ita ce NCT04926389.Ranar rajistar gwaji ita ce 06/15/2021 a https://clinicaltrials.gov/ct2/show/NCT04926389.Shigar marasa lafiya a cikin binciken ya fara ne a ranar 5 ga Fabrairu, 2020 kuma ya ƙare a kan Nuwamba 28, 2021.
An dauki marasa lafiya daga asibitin orthodontic na Faculty of Dentistry na Jami'ar Alexandria.An tantance batutuwa kuma an tantance su bisa ma'auni masu zuwa: lafiyar gabaɗaya, rashin ciwo na yau da kullun, babu magani na baya-bayan nan, isassun tsaftar baki, da kyallen jikin ɗan lokaci.An ba wa marasa lafiya da ke halartar taron da iyayensu cikakken bayani game da hanyoyin binciken, sabili da haka, an sami izini da aka ba da izini daga kowane batu da aka haɗa.An gudanar da duk hanyoyin bincike daidai da jagororin da suka dace da kuma ƙa'idodin da aka tsara a cikin sanarwar Helsinki.
Kafin fara janyewar canine, an zaɓi marasa lafiya 20 kuma an ba su bazuwar zuwa rukunin A ko rukuni B (10 a kowace rukuni) don ƙarancin laser mai ƙarfi.An yi bazuwar ta hanyar amfani da tsari mai sauƙi tare da rabon rarraba na 1: 1.An shirya wani akwati dauke da takarda guda ashirin na ninke, goma daga cikinsu an rubuta su da kalmomin “Group A” sauran goman da kalmomin “Group B”.An nemi kowane ɗan takara ya zaɓi takarda mai ninke daga cikin akwati kuma a sanya shi zuwa ɗayan ƙungiyoyi biyu daidai da haka.An sake maimaita hanya iri ɗaya a kowace ƙungiya, ana zayyana gefe ɗaya na maxillary baka a matsayin "gwaji" da kuma gefen kishiyar a matsayin "sarrafa" a cikin zane-zanen baki.
Bugu da ƙari ga bayanan ƙaho na yau da kullun (hotunan intraoral da na waje, radiyo, da abubuwan haƙori), batutuwan da aka shirya don ƙayyadaddun jiyya na ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun jiyya an sanya su ta hanyar tattara tarihin likitancin su da haƙori.An kuma bukaci majiyyata da su yi cikakken tsaftace baki da goge goge tare da umarni a cikin tsaftar baki (amfani da buroshin hakori, floss da goge-goge).
Maxillary da mandibular gyarawa tare da madaidaiciyar waya Roth kayan aikin (Mini 2000; Ormco, Amurka) tare da 0.022 ″ \ (\ x) 0.028 ″ ramummuka an gyara su a cikin duk marasa lafiya da aka ɗauka, inda aka daidaita tsarin gyaran ga ƙungiyoyin biyu kuma mai aiki ɗaya ya ƙaddara..Daga baya, an tura majiyyaci don cirewar premolar na farko na maxillary don ba da isasshen lokaci don soket ɗin ya warke bayan hakar kafin a fara hakar kamar watanni 2 bayan hakar.Adaidaita sa'an nan ta fara kuma jeri ya cika lokacin da 0.016 ″ x 0.022 ″ bakin karfe waya za a iya sakawa cikin duk hakora masu girma.
Kafin fara ja da baya na canine, manyan premolars na biyu na farko da na farko an haɗa su tare da waya mai siffar 0.009-inch-takwas akan ɓangarorin gwaji da sarrafawa na ƙungiyoyin biyu.Bugu da ƙari, an ɗaure maxillary incisors tare kamar yadda na baya don taimakawa wajen daidaitawa da kuma hana yiwuwar rabuwarsu.
Canine retraction a cikin kungiyoyin A da B da aka yi amfani da nickel-titanium (NiTi) rufaffiyar maɓuɓɓugan murhu (Ormco, Amurka), duka a kan gwaji da kuma kula da bangarorin, shimfiɗa a tsakanin ƙugiya na canine brackets da ƙugiya a kan molar canal, tare da wani karfi na 150 g an auna dynamometer (Morelli, Brazil).
An yi amfani da Laser diode (Wiser; Doctor Smile-Lambda Spa, Brendol, Italiya) azaman laser mai ƙarancin ƙarfi, yana fitar da hasken infrared tare da tsawon 980 nm da ƙarfin fitarwa na 100 mW a cikin ci gaba da yanayin.An yi amfani da igiyar igiyar igiyar jirgin sama (AB 2799; Doctor Smile-Lambda Spa, Brendola, Italiya) don rarraba tabo mai tsayi 1 cm2 tare da saman saman tudu, yana sanya tip ɗin fiber tare da maxillary baka a tsakiyar uku na maxilla.Tushen canine a gefen gwaji (bisa ga umarnin masana'anta, mafi ƙarancin 1.5 cm lokacin da ba a mayar da hankali ba) don 8 seconds (Fig. 1).Jimlar yawan ƙarfin kuzarin da aka yi amfani da shi a kowane bangare shine 8 J/cm2 (1 J/cm2 a sakan daya).Ana nuna ma'auni na laser da aka yi amfani da su a cikin Table 1. An dauki matakan kariya kafin amfani da laser, kuma duka masu haƙuri da ma'aikaci sunyi amfani da tabarau da masana'anta suka bayar, dangane da tsawon da aka yi amfani da su.
An gudanar da tip ɗin fiber a nesa na 1.5 cm daga tushen maxillary canine a gefen gwaji bisa ga umarnin masana'anta.
An yi amfani da fasaha na tsaga-baki a cikin ƙungiyoyin biyu, kuma kowane ɗan takara ya kasance bazuwar don karɓar LILI a gefe ɗaya na maxillary baka kuma a gefe guda a matsayin sarrafawa.A cikin rukuni na A, batutuwa sun karbi LILT a kan kwanakin 0, 3, 7, 14 sannan kowane mako 2, yayin da a cikin rukuni B an yi amfani da shi a kowane mako 3 a gefen gwaji don dukan lokacin nazarin (12 makonni) na LILT.Har ila yau, katakon Laser an daidaita shi a gefen kulawa na ƙungiyoyin biyu, yana ba da sakamako na placebo a matsayin wani ɓangare na tsarin makantar da marasa lafiya.Saboda yanayin sa baki a wannan mataki, ba za a iya yaudarar ma'aikacin ba.
Kafin tarin samfurin, an tsabtace ɓangarorin biyu na maxillary canines tare da swabs na auduga, keɓe tare da masu tayar da kai, tsotsa, da rolls na auduga, sannan a bushe a hankali don 5 s.An ɗauki samfurori daga ɓangarorin nesa na maxillary canines ta amfani da daidaitattun takaddun takarda masu tacewa (Whatman, Maidstone, UK) kuma a yanka su zuwa daidaitattun masu girma dabam na 2 × 10 mm2.Saka kowane tsiri a hankali a cikin ratar har sai kun ji ɗan juriya, sannan ku bar shi a wuri na tsawon daƙiƙa 60 yayin kiyaye hatimi mai kyau (Hoto 2).Bayan cirewa, an sanya sabbin tsiri kowane minti 1 don samun tsiri 4 a kowane wuri.An kuma ɗauki matakai don guje wa lalacewar injina ga fisshen gingival.Zubar da samfuran da suka gurɓace da yau ko jini kuma a tattara sabbin samfura.An dauki samfurori na GCF a asali (kafin farawa na koma baya), daga ɓangarorin canine mai nisa a cikin ƙungiyoyi A da B, a kan bangarorin gwaji da sarrafawa, sai dai kwanakin 7, 14, da 21.
Abubuwan ra'ayi na alginate (Ca37; Cavex, Haarlem, Netherlands) an yi su kafin su koma canine kuma an sake maimaita su kowane mako 3 a lokacin nazarin 12-mako a kowace ziyara.A kowace ziyara, an cire waya da maɓuɓɓugan ruwa, an ɗauki ra'ayi na alginate, kuma an jefa lissafin.Sannan ana gyara ƙirar haƙori a yi masa alama da sunan majiyyaci, lamba da kwanan wata.Daga nan aka duba samfurin filasta (inEos X5 CAD/CAM na'urar daukar hoto na dakin gwaje-gwaje; Dentply Sirona, PA, Amurka) don ƙirƙirar hoto mai girma uku (3D) na ƙirar haƙori.An yi ma'aunin da ake buƙata ta amfani da nau'in AutoCAD 2013 (AutoCAD; Autodesk, Amurka).Ma'aikatan asibiti ba su da masaniya game da bangarorin gwaji da sarrafawa a lokacin ma'auni don guje wa son zuciya mara kyau, kuma an yi gwajin amincin mai bincike tare da maimaita ma'auni ta wannan ma'aikaci bayan mako guda don bincika kurakuran auna.Kuskuren aunawa da aka kiyasta shine 6%.
An sami alamomi da yawa akan simintin haƙora, gami da suture na tsaka-tsaki, matsakaicin matsakaicin ninki uku na hagu da dama, da ƙugiya na hagu da dama maxillary canines.Layin tsaye yana gudana daga tsaka-tsaki na hagu da dama folds na uku da tubercles na hagu da dama maxillary canines zuwa tsaka-tsakin suture na palatine.An dauki ma'auni na gaba-baya tsakanin layin canine na biyu da kuma layi na uku don tantance raguwar canine (Figs. 3, 4).
Nemo alamun ƙasa akan hotunan haƙori da aka bincika don auna ja da baya.(Daya).Suture na tsakiya.(b, d).Tubercles na hagu da dama maxillary canines, bi da bi.(c, e).Layukan da suka dace da ƙarshen ciki na folds na hagu da dama na uku, bi da bi.
Bayan an cire su daga gingival crevice, ƙungiyoyi na ɗigon takarda tace guda huɗu da aka tattara a wuri ɗaya an sanya su a cikin bututun Eppendorf (Capp, Denmark) mai ɗauke da 100 µl na salin phosphate-buffered.An rufe bututun Eppendorf kuma an yi wa lakabi da samfuran nan da nan an sanya su a 3000 rpm na 10 min ta amfani da centrifuge (Hettich Universal 320R BC-HTX320; GMI, MN, Amurka) don dawo da samfuran GCF daga tsiri.An adana bututun Eppendorf a -20 ° C har sai an bincikar sinadarai.An gudanar da nazarin matakan IL-1β ta hanyar amfani da gwajin immunosorbent mai alaƙa da enzyme (ELISA; Cloud-Clone, Howe, USA).An ƙaddamar da ƙaddamar da IL-1β ta hanyar kwatanta ma'auni na gani (OD) na samfurori da aka samo tare da ma'auni mai mahimmanci kuma bisa ga ƙididdige ma'auni na regression na layi na daidaitattun layi.A ƙarshe, an gabatar da sakamakon don matakan IL-1β a cikin pg / ml / 60 s25.An nuna jadawalin ƙirar binciken a cikin hoto na 5, wanda ke taƙaita tsarin binciken.
An yi nazarin ƙididdiga ta amfani da IBM SPSS don sigar Windows 23.0 (IBM; Armonk, NY, Amurka).An rarraba dukkan ma'auni masu yawa da ma'ana, daidaitaccen karkata (SD) da 95% tazarar amincewa (CI) an ƙididdige su kuma an yi amfani da gwaje-gwaje masu dacewa.Ƙididdigar ƙididdiga (retraction na canine da matakin IL-1β) an kwatanta tsakanin ƙungiyoyin nazarin biyu ta yin amfani da samfurin t-test masu zaman kansu, yayin da aka kwatanta tsakanin sassan laser da masu sarrafawa a cikin kowane rukuni ta hanyar amfani da t-tests.Janyewar kare da matakan IL-1β a lokuta daban-daban a cikin kowane rukuni an kwatanta su daban ta amfani da maimaita ma'auni na bambance-bambancen da ke biye da kwatancen nau'i-nau'i da yawa ta amfani da matakan mahimmin daidaitawar Bonferroni. An saita mahimmanci a ƙimar p <0.05. An saita mahimmanci a ƙimar p <0.05. Значимость была установлена ​​​​при значении p <0,05. An saita mahimmanci a ƙimar p <0.05.显着性设定为p 值< 0.05.显着性设定为p值< 0.05. Значимость была установлена ​​​​на уровне p <0,05. An saita mahimmanci a p<0.05.
A lokacin nazarin, babu wani batu da ya bar baya ko dai a lokacin da aka riga aka shiga tsakani ko kuma lokacin ragowar binciken.Dukkan batutuwa 20 da aka fara daukar ma'aikata sun kammala duk tsawon lokacin nazarin mako 12 (babu 10 a kowane rukuni).Ana nuna kwararar mai haƙuri don ɗaukacin gwaji a cikin Hoto 6 ta amfani da tsarin tafiyar CONSORT.An gabatar da bayanan alƙaluma don batutuwan da aka yi rajista a Rukunin A da B a cikin Tebur 2. Babu wasu lokuta na raguwa a cikin ƙirar binciken, wanda aka yi kowane mako uku don auna raguwa na canine.Bugu da ƙari, duk samfuran GCM da aka karɓa an yi su a hankali kuma an bincika su.
An kwatanta adadin maxillary canine retraction a lokuta daban-daban a cikin Table 3, game da duka kungiyoyin A da B. A cikin rukunin A, mafi girman ma'anar nisa (± SD) tafiya ta hanyar maxillary canine an ruwaito a cikin mako na 3 don zama 1.18 (± 0.04) mm a gefen laser, kuma 0.85 (± 0.04) mai mahimmanci a tsakanin su, mm p. 1). An kwatanta adadin maxillary canine retraction a lokuta daban-daban a cikin Table 3, game da duka kungiyoyin A da B. A cikin rukunin A, mafi girman ma'anar nisa (± SD) tafiya ta hanyar maxillary canine an ruwaito a cikin mako na 3 don zama 1.18 (± 0.04) mm a gefen laser, kuma 0.85 (± 0.04) mai mahimmanci a tsakanin su, mm p. 1). Величина ретракции верхнечелюстного клыка в разные моменты времени описана в таблице 3 для обеих.В группе А наибольшее среднее расстояние (± SD) rone lazera и 0,85 (± 0,04) мм на STORINE CONTROLIA, при этом разница межdu и статиски значима (p <0,000). Adadin raguwa na maxillary canine a lokuta daban-daban an kwatanta shi a cikin Table 3 don duka kungiyoyin A da B. A cikin rukuni na A, matsakaicin matsakaicin matsakaici (± SD) ya yi tafiya ta hanyar maxillary canine a mako 3 shine 1.18 (± 0.04) mm a gefen Laser da 0.85 (± 0.04) mm bambanci tsakanin su (0.0).Ga ƙungiyoyin A da B, an kwatanta matakin maxillary canine retraction a lokuta daban-daban a cikin Table 3.在A 组中，上颌尖牙移动的最大平均距离(± SD)两者之间的差异具有统计学意义（p <0.001）。在 a 组 中 ， 上 颌 移动 的 最 大 距离 距离 距离 在 在 第 3 报告 为 激光 为 激光 为 激光 为 激光 來 1 .8侧 为 0.85 (± 0.04) mm ， 两 之间 的 具有 具有 具有 具有 具有 具有 具有 具有具有 具有 具有 具有 具有 具有 具有 具有 具有 具有 具有 具有 具有学意义） (p <0.001) В группе А максимальное среднее расстояние (± SD) е лазера и 0,85 (± 0,04) мм на стороне контроля, разница между ними была Статистическая значимость (p <0,001). A cikin rukuni A, matsakaicin matsakaicin nisa (± SD) na maxillary canine motsi a mako 3 shine 1.18 (± 0.04) mm a gefen laser da 0.85 (± 0.04) mm a gefen kulawa, bambanci tsakanin su suna da mahimmanci (p <0.001). Duk da haka, ma'anar motsin haƙori ya ragu a cikin mako na 6 a kan duka laser da bangarorin sarrafawa, sa'an nan kuma a hankali ya karu daga baya a kan makonni 9th da 12th, tare da adadin motsin hakori yana da mahimmanci a gefen laser idan aka kwatanta da gefen kulawa (p <0.001), a duk lokacin lokaci. Duk da haka, ma'anar motsin haƙori ya ragu a cikin mako na 6 a kan duka laser da bangarorin sarrafawa, sa'an nan kuma a hankali ya karu daga baya a kan makonni 9th da 12th, tare da adadin motsin hakori yana da mahimmanci a gefen laser idan aka kwatanta da gefen kulawa (p <0.001), a duk lokacin lokaci.Duk da haka, ma'anar maƙasudin haƙori ya ragu a mako na 6 a kan duka laser da bangarorin sarrafawa, sannan a hankali ya karu a cikin makonni 9 da 12, tare da adadin ƙaurawar hakori ya fi girma a gefen laser.Laser idan aka kwatanta da ƙungiyar kulawa.стороны (p <0,001) во все моменты времени. gefe (p <0.001) a kowane lokaci.然而，激光侧和对照侧的平均牙齿科动量在第6 下降，然后在第9 周和笎12比，激光侧的牙齿移动量明显更高侧（p <0.001），在所有时间点。然而 下降 和 对照侧 的 牙齿渐 增加 与 对照 相比 ， 的 移动量 明显 更 高侧 （p <0.001 ），在所有时间点。 Однако среднее количество движений зубов на стороне лазера. величилось через 9 и 12 недель, а количество движений роной (p <0,001) во все моменты времени. Duk da haka, ma'anar yawan motsin haƙori a gefen laser da gefen kulawa ya ragu a mako na 6 sannan a hankali ya karu bayan 9 da 12 makonni, kuma yawan motsin hakori a gefen laser ya kasance mafi girma idan aka kwatanta da gefen kulawa (p <0.001) a duk lokacin lokaci. Jimlar yawan motsin haƙori (± SD) a kan lokacin nazarin 12-mako ya kasance mafi girma a kan gefen laser tare da 4.45 (± 0.13) mm, idan aka kwatanta da wanda ke gefen kulawa wanda shine 3.16 (± 0.14) mm (p <0.001). Jimlar yawan motsin haƙori (± SD) a kan lokacin nazarin 12-mako ya kasance mafi girma a kan gefen laser tare da 4.45 (± 0.13) mm, idan aka kwatanta da wanda ke gefen kulawa wanda shine 3.16 (± 0.14) mm (p <0.001). Общая величина смещения зубов (± SD) за 12-недельный период мм по сравнению с контрольной стороной, которая составляла 3,16 (± 0,14) мм (p <0,001). Jimlar adadin ƙaurawar haƙori (± SD) a kan lokacin nazarin 12-mako ya kasance mafi girma a gefen laser, 4.45 (± 0.13) mm, idan aka kwatanta da gefen kulawa, wanda shine 3.16 (± 0.14) mm (p <0.001).在为期12 周的研究期间，激光侧的牙齿移动总量(± SD) 0.001).在为期12 周的研究期间，激光侧的牙齿的牙齿纻动总量(± SD) 显着更高。 16) (± 0.16) (± 0.16) (± 0.16 (± 0.16) (± 0.16) (± 0.16) В течение 12-недельного периода исследования общее 4,45 (± 0,13) мм по сравнению с 3,16 (± 0,14) мм в контрольной группе (p <0,001). A lokacin binciken 12-mako, jimlar motsin haƙori (± SD) ya kasance mafi girma a gefen laser a 4.45 (± 0.13) mm idan aka kwatanta da 3.16 (± 0.14) mm a cikin ƙungiyar kulawa (p <0.001).
A cikin rukuni na B, an bi irin wannan tsari mai kama da wanda aka nuna a rukunin A, tare da mahimmancin ƙimar motsin hakori da aka rubuta a gefen laser, idan aka kwatanta da gefen kulawa a kowane lokaci (p <0.001). A cikin rukuni na B, an bi irin wannan tsari mai kama da wanda aka nuna a rukunin A, tare da ƙimar mafi girman ƙimar motsin haƙori a kan gefen laser, idan aka kwatanta da gefen kulawa a kowane lokaci (p <0.001). В группе B наблюдалась аналогичная картина, продемонстрированная в группе A, , зарегистрированными на стороне лазера, по сравнению с контрольной стороной все моменты времени, 0 (p <1). Rukunin B ya nuna irin wannan tsari zuwa rukunin A, tare da ƙimar motsin haƙori mafi girma da aka yi rikodin akan gefen laser idan aka kwatanta da gefen kulawa a kowane lokaci (p <0.001).在B 组中，遵循与A组相似的模式，与所有时间点的对照侧相比，激光侧记录的相比，激光侧记录的發式0.001). <0.00 В группения B, по аналогии с группой A, зарегистрированные значения перемещения ению с контрольной стороной во все моменты времени (p <0,001). A cikin rukuni na B, kama da rukunin A, ƙimar da aka rubuta na motsin haƙori sun kasance mafi girma a gefen laser idan aka kwatanta da gefen kulawa a kowane lokaci (p <0.001).Bayan makonni 3, matsakaicin motsi na haƙori (± SD) an rubuta shi tare da ƙimar 1.14 (± 0.04) mm a gefen laser da 0.87 (± 0.03) mm a gefen kulawa.Motsin hakori daga baya ya ragu a mako na 6 sannan a hankali ya karu. Jimlar adadin raguwa na canine (± SD) a kan lokacin nazarin 12-mako a kan laser da bangarorin sarrafawa, shine 4.35 (± 0.12) mm, da 3.10 (± 0.06) mm, bi da bi, kuma bambanci tsakanin su yana da mahimmanci (p <0.001). Jimlar adadin raguwa na canine (± SD) a kan lokacin nazarin 12-mako a kan laser da bangarorin sarrafawa, shine 4.35 (± 0.12) mm, da 3.10 (± 0.06) mm, bi da bi, kuma bambanci tsakanin su yana da mahimmanci (p <0.001).Jimlar koma baya na canine (± SD) akan lokacin binciken 12-mako akan laser da bangarorin sarrafawa shine 4.35 (± 0.12) mm da 3.10 (± 0.06) mm, bi da bi, kuma bambanci tsakanin su yana da mahimmanci.(R <0,001). (p <0.001).在为期12 周的研究期间，激光侧和对照侧的犬齿回缩总量(± SD)间的差异具有统计学意义(p <0.001).在 为期 12 周 的 研究 ， 激光 侧 和 对照侧 的 回缩(± 0.06) mm ， 之间 的 差异 具有 统计学 意义 (p (p <0.001)). В течение 12-недельного периода исследования общая (± SD) 0,12) мм и 3,10 (± 0,06) мм соответственно, и разница была статистически значимой (p <0,001). A cikin lokacin nazarin mako na 12, jimlar (± SD) raguwar canine a gefen laser da kuma kulawa shine 4.35 (± 0.12) mm da 3.10 (± 0.06) mm, bi da bi, kuma bambancin ya kasance mai mahimmanci (p <0.001). .Teburin 4 yana kwatanta kwatankwacin matakin raguwar canine a wurare daban-daban na lokaci tsakanin laser da gefen kulawa a kowane rukunin binciken.
Kodayake matakin janyewar canine ta hanyar laser ya fi girma a rukunin A fiye da rukunin B a kowane lokaci, ba a yi la'akari da wannan bambance-bambancen ƙididdiga ba idan aka kwatanta da rukunin B (p = 0.08-0.55).Game da karuwar kashi (± SD) a cikin raguwar canine da aka samu tare da kowace yarjejeniya, ka'idar da aka yi amfani da ita a cikin rukuni na A ya karu da 40.78 (± 4.81)%, yayin da tsarin da aka yi amfani da shi a cikin rukuni A ya karu da 40 .22 (± 4.80)% a cikin rukuni B. Laser aikace-aikacen yarjejeniya da aka karɓa.Duk da haka, ko da yake wannan kaso ya ɗan fi girma a rukunin A fiye da rukunin B, bambamcin da ke tsakanin su bai kasance mai mahimmanci ba (p = 0.82).Bugu da ƙari, an gano cewa yanayin motsi na hakora a cikin ƙungiyoyi biyu yana da ɗanɗano iri ɗaya (Fig. 7).
Ragewar Laser na canine na gefe (mm) a wurare daban-daban a cikin ƙungiyoyin binciken biyu a lokacin nazarin mako 12.
Shafin 5 yana kwatanta matakan IL-1β a cikin kungiyoyi A da B a duk lokacin da aka auna akan laser da bangarorin sarrafawa.A cikin rukunin A, bambanci tsakanin gefen laser da gefen kulawa a tushe ba shi da mahimmanci ga ƙimar IL-1β (p = 0.56). An rubuta matakin mafi girma na IL-1β (± SD) a ranar 7 a kan duka bangarorin laser da kuma kula da su, tare da ƙimar 0.152 (± 0.004) pg / ml / 60 s, da 0.127 (± 0.004) pg / ml / 60 s, bi da bi, kuma bambanci tsakanin su ya kasance mai mahimmanci (0.0). An rubuta mafi girman matakin IL-1β (± SD) a rana ta 7 akan duka bangarorin laser da kuma kulawa, tare da ƙimar 0.152 (± 0.004) pg/ml/60 s, da 0.127 (± 0.004) pg/ml/60 s, bi da bi, kuma bambanci tsakanin su ya kasance mai mahimmanci (0.0).An yi rikodin mafi girman matakin IL-1β (± SD) a ranar 7 akan duka laser da bangarorin sarrafawa tare da ƙimar 0.152 (± 0.004) pg/ml/60 s da 0.127 (± 0.004) pg/mL./60 с соответственно, а разница между ними была статистически значимой (p <0,001). / 60 s, bi da bi, kuma bambancin da ke tsakanin su yana da mahimmancin ƙididdiga (p <0.001).在第7 天，激光侧和对照侧均记录到最高水平的IL-1β (± SD)。 ，它们之间的差异具有统计学意义（p <0.001）。在第7 天，激光侧和对照侧均记录到最高水平的IL-1β (± SD)。 0.001).A rana ta 7, an rubuta mafi girman matakan IL-1β (± SD) akan duka laser da bangarorin sarrafawa tare da ƙimar 0.152 (± 0.004) pg / ml / 60 s da 0.127 (± 0.004) pg / mL./ 60 s.Разница между ними была статистически значимой (p <0,001). Bambanci tsakanin su yana da mahimmancin ƙididdiga (p <0.001). An ba da rahoton raguwa a hankali a cikin matakan IL-1β bayan haka, a kan kwanaki 14 da 21, a kan dukkanin laser da sassan sarrafawa, tare da dabi'u a gefen Laser yana da girma fiye da waɗanda ke gefen kulawa (p <0.001). An ba da rahoton raguwa a hankali a cikin matakan IL-1β bayan haka, a kan kwanakin 14 da 21, a kan duka laser da bangarorin sarrafawa, tare da dabi'u a gefen laser suna da girma fiye da waɗanda ke gefen kulawa (p <0.001). Просмотры :                               ом значения на стороне лазера были значительно выше, чем на стороне контроля (p <0,001). Bayan haka, an ba da rahoton raguwa a hankali a cikin matakan IL-1β a kwanakin 14 da 21 a kan dukkanin sassan laser da kuma kula da su, tare da dabi'u a gefen Laser yana da girma fiye da waɗanda ke gefen kulawa (p <0.001). .此后，在第14 天和第21 天，激光和对照侧的IL-1β 水平逐渐下降。 .此后，在第14 天和第21 天，激光和对照侧的IL-1β 水平逐渐下降。 После этого на 14-y и 21-y дни уровни ИЛ-1β postepenno ыли значительно выше, чем на стороне контроля (p <0,001). Bayan haka, a cikin kwanakin 14th da 21st, matakan IL-1β a hankali sun ragu a gefen laser da kuma a cikin sarrafawa, yayin da dabi'u a gefen laser sun kasance mafi girma fiye da gefen kulawa (p <0.001).
A cikin rukuni na B, an lura da irin wannan tsari a cikin rukunin A game da matakan IL-1β, tare da ƙananan bambance-bambancen da aka lura a tushe tsakanin sassan laser da masu sarrafawa (p = 0.02). Bayan kwanaki 7, an kai kololuwar matakin IL-1β (± SD) a bangarorin biyu, tare da 0.139 (± 0.004) pg / ml / 60 s a gefen laser, da 0.122 (± 0.003) pg / ml / 60 s a gefen kulawa, tare da ƙimar a gefen Laser mafi girma (0.0 statistically la'akari). Bayan kwanaki 7, an kai kololuwar matakin IL-1β (± SD) a bangarorin biyu, tare da 0.139 (± 0.004) pg / ml / 60 s a gefen laser, da 0.122 (± 0.003) pg / ml / 60 s a gefen kulawa, tare da ƙimar a kan gefen Laser mafi girma (pist 0) .Bayan kwanaki 7, an kai matakin kololuwar IL-1β (± daidaitattun daidaituwa) a bangarorin biyu: 0.139 (± 0.004) pg / ml / 60 s a gefen laser da 0.122 (± 0.003) pg/ml/60 s.на крольный стороне, при этом значения на стороне лазера считались статистически bolее выскими (p <0,001). a gefen kulawa, yayin da ƙimar da ke gefen Laser an yi la'akari da ƙididdiga mafi girma (p <0.001). 7. s在控制侧，激光侧的值在统计上更高（p <0.001）。 7 天 后 ， 两 侧 达到 达到 il-1β 水平 （（±） （（±） 122 (0.003) pg/ml/60 s 在 侧 激光 激光 激光, , , 侧的值在统计上更高（p <0.001）。Bayan kwanaki 7, an samu matakan IL-1β (± SD) a bangarorin biyu: 0.139 (± 0.004) pg / ml / 60 s a gefen laser da 0.122 (± 0.003) pg / ml / 60 s a gefen kulawa., лазер Значения на стороне были статистически выше (p <0,001). , Ƙimar Laser a kowane gefe sun kasance mafi girma a ƙididdiga (p <0.001).Matakan IL-1β daga baya sun ragu a hankali a bangarorin biyu a kwanaki 14 da 21, kuma matakan da aka rubuta a gefen laser sun kasance mafi girma idan aka kwatanta da bangaren kulawa a duka lokutan lokaci (p = 0.001-0.002).Kwatanta matakan IL-1β a lokuta daban-daban tsakanin gefen laser da gefen kulawa a cikin kowane rukunin binciken an kwatanta shi a cikin Table 6.
Lokacin kwatanta matakan IL-1β tsakanin ƙungiyoyin nazarin biyu, an rubuta wani bambanci maras muhimmanci a gefen laser a asali (p = 0.96). A ranakun 7th da 14th, an yi rajistar bambance-bambance masu mahimmanci tsakanin bangarorin laser a cikin ƙungiyoyin biyu, tare da ƙimar mafi girma na bangarorin laser a rukunin A (p <0.001). A kwanakin 7th da 14th, an yi rajistar bambance-bambance masu mahimmanci tsakanin bangarorin laser a cikin ƙungiyoyin biyu, tare da ƙimar mafi girma na bangarorin laser a rukunin A (p <0.001). На 7-й и 14-й дни зарегистрированы статистически. ие значения принадлежат лазерным сторонам в группе А (р <0,001). A kwanakin 7 da 14, akwai bambance-bambance masu mahimmanci tsakanin sassan laser a cikin ƙungiyoyin biyu, tare da ƙimar mafi girma na bangarorin laser a cikin rukunin A (p <0.001).在第7 天和第14 天，两组激光侧的差异有统计学意义，A 组激光侧的值较高（p <0.0.0. A На 7 и 14 дни разница между двумя группами была статистически в группе А (p <0,001). A kwanakin 7 da 14, bambanci tsakanin ƙungiyoyin biyu ya kasance mai mahimmanci a kan gefen laser, tare da ƙimar mafi girma a gefen laser a cikin rukuni A (p <0.001).Bayan kwanaki 21, babu wani babban bambanci tsakanin ƙungiyoyin biyu (p = 0.26).Matakan IL-1β a cikin ƙungiyoyi biyu suna da hali iri ɗaya, sun kai iyakar a ranar 7th kuma a hankali suna raguwa a kan 14th da 21st days (Fig. 8).
Manufar wannan binciken shine da farko don ƙididdigewa da kwatanta tasirin LILR akan raguwar canine ta amfani da ka'ida ta amfani da ƙa'idar da ta haɗa da hasken wutar lantarki mai girma a kwanakin 0, 3, 7, 14 da kowane mako 2 bayan haka (Rukunin A) tare da marasa lafiya da suka shiga kwanan nan.an sami ƙarancin tunawa idan aka kwatanta da tsarin da aka yi tazarar laser a cikin makonni 3 (rukuni B).Ko babbar yarjejeniya ce ta babban mitar7,13,26 ko yarjejeniya ta mako 315,17,18, duka ka'idojin an bayyana su a cikin adabi.Dangane da sakamakon da aka gabatar a cikin binciken na yanzu, ba a ƙi amincewa da ra'ayi na banza ba, kuma ta hanyar aiwatar da ka'idoji guda biyu da aka yi nazari, an sami daidaitattun adadin ƙungiyoyin kare.
Tsarin binciken na yanzu shine gwajin gwaji na asibiti (RCT).Ana ɗaukar RCTs a matsayin ma'auni na zinariya don kimanta tasirin sa baki27.An kuma yi amfani da dabarar raba-baki, babban fa'idarsa ita ce an kawar da bambance-bambance tsakanin batutuwa, tare da kowane majiyyaci yana aiki a matsayin mai sarrafa kansa, don haka rage adadin mahalarta da ake buƙata.
Duk batutuwan da aka haɗa a cikin binciken sun buƙaci cirewar maxillary na farko premolar wanda ke biye da ja da baya na canine a matsayin wani ɓangare na maganin orthodontic.Tun da cirewa zai iya canza ƙimar RTM ta hanyar ƙara yawan ayyukan alamomin kumburi, wanda hakan zai iya rufe tasirin LILT kuma ya ba da karatun ƙarya na matakan IL-1β lokacin amfani da laser, an yi maganin cirewa kafin magani, wanda ya ba da sakamako mai kyau.Maganin hakar soket na warkarwa yana ba da isasshen lokaci kuma yana shawo kan tasirin haɓakar haɓakar yanki28.Hakanan wasu mawallafa sun ɗauki wannan rigakafin, 11 waɗanda suka bincika tasirin LILT akan ƙimar OTM yayin ja da baya a cikin karnuka ta hanyar auna matakan ma'aunin halittu kamar IL-1β da canza yanayin girma β1 (TGF-β1) a cikin GCF.
Nau'in Laser da aka yi amfani da shi a cikin wannan binciken shine diode semiconductor laser da aka yi amfani da shi a 980 nm bisa ga shawarwarin masana'anta don ingantaccen biostimulation.Ana iya yin bayanin wannan ta gaskiyar cewa tsawon tsayin igiyoyin Laser (650-1200 nm), zurfin nama yana shiga29.Koyaya, an yi amfani da wannan tsayin shawarar da aka ba da shawarar a cikin wasu karatun da yawa, yana haifar da ingantaccen tasirin hanzari na 8.30 da mummunan tasirin 14.
Wani muhimmin mahimmanci da ke tasiri tasirin maganin LILI da biostimulation shine kashi ko yawan makamashi.Lokacin nazarin wallafe-wallafen, an gano cewa akwai babban nau'i mai yawa a cikin adadin makamashi na LILI don haɓaka GTM.Wasu mawallafa suna ba da rahoton sakamako mai kyau lokacin amfani da ƙananan ƙarancin makamashi daga 0.7131, 532.33, 7.514 zuwa 8 J / cm234.35, yayin da wasu masu bincike kuma suna ba da rahoton tasirin LILR akan ƙimar GTM a mafi girman ƙarfin makamashi, misali, 25 J / cm2.cm27.36.A cikin aikin na yanzu, an ba da kashi na ƙananan ƙarfin laser na 8 J / cm2 ta hanyar bayyanar guda ɗaya zuwa tushen canine na maxillary don 8 seconds ta amfani da saman saman tudu don rarraba alamar katako na 1 cm2.Akwai alaƙa kai tsaye tsakanin girman katako da zurfin shigar laser, wanda hakan ya ba da hujjar yin amfani da saman lebur a cikin wannan binciken29,37.Irin wannan ƙa'idar aikace-aikacen guda ɗaya tare da girman girman katako mai girma ana yin shi tare da daidaitawa da daidaitawa 8 da ja da baya na canine 38.
IL-1β an san shi azaman cytokine mai mahimmanci na pro-mai kumburi a farkon OTM kuma ana ɗaukar alamar resorption kashi.Sabili da haka, an tantance matakan IL-1β ta hanyar laser a cikin binciken da yawa11,39,40 a cikin ƙoƙari na ƙayyade alaƙar su.A cikin gwaji na yanzu, an kimanta matakan IL-1β a cikin GCF a kan gwaje-gwajen gwaji da kuma kula da kowane rukuni ta hanyar yin amfani da nau'i biyu na LILI a kwanakin 0, 7, 14, da 21.
A cikin binciken da aka yi a yanzu, raguwar canine ta hanyar laser a cikin kungiyoyi A da B ya kasance mafi girma fiye da a cikin ƙungiyar kulawa a duk lokacin da aka kiyasta, yana girma a mako na 3, yana raguwa har mako guda a mako 6, sa'an nan kuma a hankali ya karu har zuwa mako 12..Peak canine motsi lura a mako 3 za a iya bayyana ta sakamakon na farko da hakori gudun hijira, ciki har da: tushen maye gurbi a cikin PDL, kasusuwa nakasawa saboda flexure da creep, da matsa lamba matsa lamba na hakori saboda karkata na conical soket Plane sakamako 41. Bugu da kari, an gano cewa duk aiki nazarin halittu tafiyar matakai da aka kara accelerated a lokacin da kashi ya kasance accelerated matsayi.Rage jinkirin da aka gani tsakanin makonni 3 zuwa 6, maiyuwa saboda lokacin jinkiri wanda zai iya bambanta daga makonni 2 zuwa 10, lokaci ne na rushewar PDL wanda ke sake sakewa kuma yana cire kashi kusa da yankin murkushewa, yana barin motsin kashi.hakora.Wani abin da ke ba da gudummawa ga wannan lura yana iya kasancewa fibers oxygenated, fibers collagen, da gyaran ƙashi na alveolar a gefen tashin hankali na iya iyakance yawan motsin haƙori.An samo irin wannan nau'i na motsin haƙori a cikin binciken ƙwanƙwasa45 kwatanta sakamakon LILI da corticotomy a kan raguwar raguwar canine, sun lura cewa motsin haƙori ya fi girma a makonni 2 da 5, sannan kuma raguwa mai zurfi a 2 da 5 makonni.mako na th.Ba a bayar da rahoton wannan a gefen laser ba a mako na 7, amma ba a gefen corticotomy ba.
Matsakaicin adadin da aka ruwaito ya karu a nesa na motsi na maxillary canine daga gefen Laser shine 40.78% a cikin rukunin A da 40.22% a cikin rukunin B. Haɓaka haɓakar haɓakar haƙori wanda ke tare da amfani da Laser ana iya bayyana shi a matakin salon salula ta hanyar ɗaukar makamashin Laser ta hanyar ɗaukar hoto mai ɗaukar hoto a cikin sarkar numfashi na lantarki.Wannan tasirin yana haifar da kunna sarkar numfashi na ɗan lokaci, wanda ke haifar da phosphorylation oxidative da canje-canje a cikin yanayin redox na mitochondria na salula da cytoplasm.Hakanan, ƙarfin tuƙi na tantanin halitta yana ƙaruwa ta hanyar haɓaka samar da ATP.Bugu da ƙari, akwai karuwa a cikin yuwuwar membrane na mitochondrial, alkalization na cytoplasm, da kuma kira na nucleic acid.Tun da an san ATP a matsayin kudin makamashi na sel, LILI yana ba da gudummawa ga aikin yau da kullun na sel ta hanyar ƙirƙirar yanayi mai kyau don motsin haƙori46.Don haka, daga sakamakonmu, zamu iya yanke shawarar cewa yin amfani da LILT a matsayin haɗin gwiwa ga maganin orthodontic zai iya samun nasarar hanzarta OTM ba tare da la'akari da ko ana amfani da shi sau da yawa kamar tsarin tsarin a cikin rukunin A (a ranakun 0, 3, 7, 14 da kowace rana).bayan kwanaki 2) makonni), ko kuma idan an yi amfani da shi ƙasa akai-akai a rukunin B (kowane makonni 3), don haka, ba a ƙi amincewa da hasashen mara amfani ba.
Matsakaicin haɓakar haɓakar haɓakar haɓakar ƙa'idodin ƙa'idodin LILT guda biyu da aka gwada a cikin wannan binciken na iya kasancewa saboda kasancewar kofa na kunna wayar salula wanda haɓakar kunna wayar salula tare da bayyanar LILT yana faruwa da farko, amma sai an sake bayyanawa (kamar yadda a cikin rukunin A), saboda cikakkiyar halayen ilimin halitta ba zai haifar da ƙarin kunnawa ba.Don haka, zamu iya ɗauka cewa tasirin LLLT a matakin salula ba zai iya tarawa ba.Game da alaƙar da ke tsakanin matakin ƙarfi da saurin motsin haƙori, an kwatanta manufar biosaturation a baya.
Bayan nazarin wallafe-wallafen da ake da su, mun kwatanta 1.4-ninka (40-41%) karuwa a WTM da aka samu a cikin bincikenmu ta amfani da ka'idojin laser guda biyu tare da sakamakon wasu rahotanni da dama.Wasu nazarin sun ba da rahoton irin wannan sakamakon11,30,48,49 yayin da wasu sun ba da rahoton ƙananan ƙimar haɓakawa da aka yi amfani da su ta amfani da LILI7,18,32,40.A daya hannun, da yawa mafi girma hanzari dabi'u fiye da waɗanda aka ruwaito a halin yanzu gwaje-gwaje, jere daga 1.65 × 17 zuwa kusan 2x OTM15, 34, 39, 50, wanda zai iya zama alaka da wasu daga cikinsu Yi amfani da kai-kulle braces ba tare da gogayya 15. Wannan bambanci a cikin sakamakon da aka buga a cikin wallafe-wallafen na iya zama saboda, daban-daban ikon yin amfani da Laser alamu, lokacin da fitarwa na Laser aikace-aikace na wallafe-wallafen na iya zama saboda, daban-daban ikon yin amfani da lokaci. da dai sauransu, wanda ke sa kwatanta kai tsaye tsakanin karatu daban-daban da wahala sosai..Duk da haka, an lura cewa ƙananan ƙarancin makamashi (misali 2.5, 5 da 8 J / cm2) suna samar da ingantaccen haɓakar haɓakawa idan aka kwatanta da yawan makamashi mafi girma, yana da kyau a lura cewa allurai da aka yi amfani da su a cikin gwaje-gwajenmu sun kasance 8 J / cm2.cm2.
Fassarar matakan IL-1β a cikin raguwa mai nisa (dangin matsawa) bayan nazarin samfurori na GCF da aka samu ya nuna karuwar ƙididdiga daga asali (watau kololuwa) a ranar 7 tare da raguwa a hankali zuwa tushe.a kan bangarori A da B, a gefen Laser kuma a gefen kulawa.Ana iya bayyana wannan ta gaskiyar cewa matakin farko na OTM yawanci yana tare da karuwa a cikin aikin osteoclast.IL-1β kuma ana la'akari da shi azaman alamar farko da aka gano da ke hade da haɓakar kashi, kuma an ba da rahoton IL-1β ya karu da ƙarfi kuma daga baya ya ragu a cikin binciken da yawa11,20,51.
Bugu da ƙari, matakan IL-1β sun kasance mafi girma a gefen laser idan aka kwatanta da ƙungiyar kulawa a cikin ƙungiyoyin binciken biyu a duk lokacin da aka auna sai dai asali, kuma akwai bambanci mai mahimmanci a tsakanin su.Wannan yana nuna cewa rashin ƙarfi na Laser radiation ya haifar da ingantaccen amsawar halitta a cikin kyallen takarda na lokaci-lokaci a gefen gwaji a cikin nau'i na ƙarfafa aikin osteoclast akan gefen da aka matsa yayin motsin haƙori na orthodontic.An nuna wannan tasiri na LLLT akan matakan IL-1β a cikin bincike daban-daban11,39,40.
Lokacin da aka kwatanta matakan laser-gefen IL-1β a cikin ƙungiyoyin binciken guda biyu, matakan sun kasance mafi girma a cikin rukunin A idan aka kwatanta da rukunin B a kwanakin 7 da 14. Wannan za a iya bayyana shi ta hanyar babban adadin abubuwan da ke nunawa ga hasken wuta na laser a cikin rukuni A yayin lokacin lura na 21-day, inda aka gudanar da irradiation a kwanakin 0, 3, 7, da 14, duk da haka an harbe shi a cikin rukuni na B1 kawai. sun kasance mafi girma a cikin ƙididdiga a gefen laser a cikin rukuni A, wannan bambancin ƙididdiga ba a bayyana a asibiti ba a cikin matakan ja da baya a cikin karnuka idan aka kwatanta da gefen laser a cikin rukuni B, saboda babu wani mahimmancin ƙididdiga.A cikin ƙungiyoyin A da B, bambance-bambancen da aka ruwaito a cikin ja da baya na canine tsakanin bangarorin laser a zahiri ya haifar da adadin motsin canine.Sabili da haka, zamu iya cewa bambance-bambancen ƙididdiga ba dole ba ne ya bayyana mahimmancin asibiti.
Ƙarƙashin ƙwayar laser mai ƙarancin ƙarfi, lokacin da aka yi amfani da shi tare da ma'auni da aka yi amfani da su a cikin wannan binciken, zai iya inganta haɓakar haƙoran haƙoran haƙora da kusan sau 1.4, ko an yi amfani da shi a ƙananan mita ko ƙananan mita, daidai da biyan kuɗi na yau da kullum, watakila.mafi dacewa ga marasa lafiya.
Ƙara haɓakar motsin haƙori na orthodontic a lokacin LILI yana tare da karuwa a matakin interleukin-1β a gefen da aka matsa, wanda ya nuna cewa yin amfani da LILI yana haifar da ingantaccen tsari na gyaran kashi.
Rubutun bayanan da aka yi amfani da su da/ko aka yi nazari a cikin binciken na yanzu suna samuwa daga mawallafa bisa ga buƙatu mai ma'ana.
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