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Chinangwa chechidzidzo ichi chaive chekuongorora chiyero chekudzosa canine kune maviri low intensity laser therapy (LLLT) irradiation regimens, kusanganisira yakakwirira uye yakaderera frequency.Varwere makumi maviri vakapatsanurwa zvisina tsarukano kuita mapoka maviri.Muboka A, rumwe rutivi rwemaxillary arch rwakanga rusina kurongeka kuti rigamuchire LILT pamazuva 0, 3, 7, 14, uye mavhiki maviri ega ega akatevera, muboka B, rimwe divi raigamuchira LILT mavhiki matatu oga oga.Munguva ye12-vhiki yekudzidza, kufamba kwezino kwaiongororwa mavhiki matatu ega ega kubva pakutanga kwe canine retraction.Mukuwedzera, mazinga e interleukin-1β (IL-1β) mu gingival sulcus fluid akaongororwa. Mhedzisiro yakaratidza kuwedzera kukuru kweiyo canine retraction rate pamativi e laser emapoka A uye B, mukuenzanisa neanodzora mativi (p <0.05), pasina misiyano yakakosha yakataurwa pakati pelaser mativi mumapoka maviri (p = 0.08-0.55). Mhedzisiro yakaratidza kuwedzera kukuru kweiyo canine retraction rate pa laser mativi emapoka A uye B, mukuenzanisa nekudzora mativi (p <0.05), pasina misiyano yakakosha yakashumwa pakati pema laser mativi mumapoka maviri (p = 0.08-0.55). Результаты выявили значительное увеличение скорости ретракции клыков на стороне лазера в группах A и B по сравнению с контрольной стох0 различий между сторонами лазера в обеих группах (p = 0,08–0,55). Zvigumisiro zvakaratidza kuwedzera kukuru kwe canine retraction speed padivi re laser mumapoka A uye B zvichienzaniswa nedivi rekutonga (p <0.05), pasina mutsauko mukuru pakati pema laser mativi mumapoka maviri (p = 0.08-0.55). ).结果显示，与对照组相比，A 组和B 组激光侧的犬齿回缩率显着增加（p <0.05光显旾，着差异（p = 0.08-0.55 ）.结果 显示 , 与 对照组 , 组和 a 组和 b 组 激光侧 犬齿 回 缩率 显着 （（组激光侧 犬齿 回 缩率 显着 （（组激光侧 犬齿回 缩率 显着（（组激光侧（（＠组（（组（p）间 显着 差异 （p = 0.08-0.55。。。. Результаты показали, что по сравнению с контрольной группой скорость ретракции клыков на стороне лазера в группах А и В быльков на стороне лазера в группах А и В быль зp не лазера не было существенной разницы между двумя группами (p = 0,08-0,55). Zvigumisiro zvakaratidza kuti, zvichienzaniswa neboka rekutonga, canine retraction rate padivi re laser mumapoka A uye B akanga akakwirira zvikuru (p <0.05), uye pakanga pasina kusiyana kwakasiyana pakati pemapoka maviri pa laser side (p = 0.08-0 .55). Zvakare, IL-1β mazinga aive akanyanya kukwirira pama laser mativi emapoka maviri, mukuenzanisa neanodzora mativi (p <0.05). Zvakare, IL-1β mazinga aive akanyanya kukwirira pama laser mativi emapoka maviri, mukuenzanisa neanodzora mativi (p <0.05). Кроме того, уровни IL-1β были значительно выше на стороне лазера в обеих группах по сравнению с контрольной стороной (p <0,05). Mukuwedzera, IL-1β mazinga akanga akakwirira zvakanyanya padivi re laser mumapoka ose ari maviri achienzaniswa nedivi rekutonga (p <0.05).此外，与对照组相比，两组激光侧的IL-1β 水平显着升高（p <0.05）.此外，与对照组相比，两组激光侧的IL-1β 水平显着升高（p <0.05）. Кроме того, уровни IL-1β были значительно повышены на стороне лазера в обеих группах по сравнению с контрольной группой (p <0,00). Mukuwedzera, IL-1β mazinga akanyanya kukwidziridzwa padivi re laser mumapoka maviri achienzaniswa neboka rekutonga (p <0.05).Nokudaro, LILI yakakwanisa kukurumidza kukurumidza kufamba kwezino, ingave yakashandiswa kakawanda kana kuti isingawanzoitiki, iyo yakabatanidzwa nekuwedzera kwehupenyu hwehupenyu, iyo yakaratidzwa mukuwedzera kwemazinga e-IL-1β padivi rakamanikidzwa.
Kurapa kwenguva refu orthodontic (kazhinji kwakapoteredza 20-30 mwedzi1) yakawanikwa ichikanganisa kutevedza kwevarwere, kuwedzera kune njodzi dzakadai semidzi resorption2, caries3, enamel decalcification3 uye periodontal matambudziko4,5.Naizvozvo, nzira dzakati wandei dzakataurwa dzakanangana nekumhanyisa orthodontic zino kufamba (OTM), kusanganisira yekuvhiya uye isiri-yekuvhiya.Pamusoro pezvo, mhedzisiro yekubatanidza nzira mbiri dzekumhanyisa uye mhedzisiro yekudzokorora imwechete yekumhanyisa maitiro pakumhanya kweOTM6 yakaongororwa.
Low intensity laser therapy (LLLT) yanga iri imwe yedzakarongwa dzisiri dzekuvhiya nzira dzekumhanyisa OTM, asi pakave nemhedzisiro inopesana mumishumo yekubudirira kwayo munzvimbo ino, nepo positive7,8 uye negative9 mhedzisiro zvakanyorwa.Izvi zvinopokana mhedzisiro zvinogona kutsanangurwa nemusiyano mulaser application paramita inoshandiswa muchidzidzo chega chega, kusanganisira mhando yelaser, nzira yekushandisa, wavelength, radiation dose, uye nguva yekufumurwa, sezvo aya ma paramita ane hukama zvakananga nemhedzisiro yekiriniki yelaser application 10.
Panyaya yemaitiro ekushandisa, akasiyana siyana laser irradiation protocol akashumwa kuti afambise kufamba kwezino.Imwe protocol inoshandiswa zvakanyanya inosanganisira kuisa laser pamazuva 0, 3, 7, 14, 21 uye 30, kudzokorora kutevedzana kwakafanana mwedzi wega wega, uye iyi protocol yakagamuchirwa nevanyori vakati wandei11,12.Vamwe vakashandisa imwe rejimeni iri padyo neyakarondedzerwa kare uye iri imwe yenzira dzinoshandiswa zvakanyanya, umo LILI inoshandiswa pamazuva 0, 3, 7, 14, uyezve mazuva gumi nemashanu ega ega kusvika pakupera kwenguva yekudzidza.13. Mukuwedzera, purogiramu yakarongwa iyo inosanganisira kushandiswa kwevhiki nevhiki kwe-low-intensity laser munguva yose yekubvisa canine.Nekudaro, iyo inonyanya kukanganisa yeaya akajairwa maprotocol chiyero chepamusoro chemhinduro dzemurwere, izvo zvinogona kukanganisa munhu wese.Saka, maprotocol anoda mashoma ekutumirwa kwevarwere anoshandiswa, semuenzaniso, kusanganisira LILI kasere pamwedzi kana 15, 16, 17, 18 mavhiki matatu ega ega.
Sezvo mauto e orthodontic achizivikanwa kuti anokonzera kugadzirisa kwemapfupa, kukura kwekuchinja kwehuputi chinhu chinodiwa pakuita uku, zvichiita kuti mazino asarudze zvakanaka19.Maererano neongororo dzinoverengeka, imwe nzira yekuongorora zvinogona kuitika zvipenyu mu periodontal ligament ndeyekuongorora chiyero che cytokines mu gingival sulcus fluid (GCF).Interleukin-1β (IL-1β) inonyanya kushanda cytokine mumapfupa emagetsi uye inoonekwa seimwe ye cytokines yakasimba mukutanga kweOTM periodontal tissue.Sezvo pane kuwirirana pakati pe-IL-1β mazinga uye kupona, fusion uye osteoclast activation, IL-1β inogona kuonekwa sechiratidzo chakakosha chekuverenga dhigirii ye orthodontic mazino kufamba, iyo yakabatana nekushanda kwealveolar bone remodeling24.
Nokudaro, chinangwa chekudzidza kwedu chaiva chekuongorora nekuenzanisa migumisiro yeNILT nemishonga inowanzoshandiswa, kusanganisira kuwanda kwekushandiswa kwemazuva 0, 3, 7, 14, uyezve masvondo maviri ega ega kana achienzaniswa nekushandiswa kwemavhiki matatu.Retraction rate muimbwa mukuedza kuderedza kuwanda kwemurwere anoyeuka.Mukuwedzera, IL-1β mazinga muGCF akaongororwa achishandisa maprotocol maviri.Iyo null hypothesis yechidzidzo chezvino ndechekuti hapana mutsauko mune chiitiko che canine retraction neLILI uchishandisa maviri ekuyedza maprotocol.
Chidzidzo chacho chaive chiyedzo chekiriniki chakarongeka chine mapoka maviri akafanana, rimwe nerimwe richiedza LILI protocol.Boka rega rega rinotora dhizaini yemuromo wekupatsanurwa, rimwe divi iboka rekutonga uye rimwe iboka rekudzidza.
Chidzidzo chacho chaisanganisira varwere ve20 vane makore 15 kusvika kumakore makumi maviri avo vaida kubviswa kwekurapa kwekutanga premolars yejaya repamusoro, rinoteverwa nekudzosa kwe canines.Sample size calculations dzaibva pakukanganisa kwealpha kwe5% uye simba rekudzidza re80%.Kuverenga uku kunobva pazvinoreva uye kutsauka kwakajairwa kwekudzoserwa kwembwa muzvidzidzo umo Doshi-Mehta naBhad-Patil7 vakashandisa LILI pamazuva 0, 3, 7, 14 uye mavhiki maviri ega ega mushure mazvo (Arm A) uye muzvidzidzo zveQamruddin et al.vamwe Muzvidzidzo gumi neshanu, LILI yakashandiswa mavhiki matatu ega ega (boka B).Mvumo yetsika yakawanikwa kubva kuEthics Council yeFaculty of Dentistry, Alexandria University, Alexandria, Egypt (IRB: 00010556-IORG: 0008839).Huwandu hwekomiti yemanyoro etsika ndeye 0111-01/2020.Yakatenderwa Ndira 21, 2020. Muedzo wakanyoreswa neClinicalTrials.gov se "Two Low Level Laser Protocols to Evaluate Retraction Velocity in Dogs."Nhamba yekunyoresa muyedzo ndeye NCT04926389.Zuva rekunyoresa kuyedza ndi06/15/2021 pa https://clinicaltrials.gov/ct2/show/NCT04926389.Kunyoreswa kwevarwere muchidzidzo kwakatanga muna Kukadzi 5, 2020 uye kwakapera munaNovember 28, 2021.
Varwere vakatorwa kubva kukiriniki ye orthodontic yeFaculty of Dentistry yeAlexandria University.Zvidzidzo zvakaongororwa uye zvakaongororwa maererano nemitemo inotevera yekukodzera: hutano huzhinji, kusavapo kwechirwere chisingaperi, hapana chekare chekurapa orthodontic, hutsanana hwakakwana hwemuromo, uye hutano periodontal tishu.Varwere vanobatanidzwa nevabereki vavo vakapiwa tsanangudzo yakazara uye yakadzama yezvirongwa zvekudzidza, uye naizvozvo, kubvumirwa kweruzivo kwakawanikwa kubva kune imwe neimwe yakabatanidzwa.Nzira dzose dzekutsvakurudza dzakaitwa maererano nemitemo yakakodzera uye mitemo yakarongwa muDeclaration yeHelsinki.
Asati atanga kudzosa canine, varwere ve20 vakasarudzwa uye vakasarudzwa kuboka A kana boka B (10 muboka rimwe nerimwe) nokuda kwepasi-intensity laser therapy.Randomization yakaitwa uchishandisa yakapusa randomisation maitiro ane chiyero chekugovera che1: 1.Bhokisi rakagadzirwa raiva nemapepa akapetwa makumi maviri, gumi acho akanga akanyorwa mashoko okuti “Boka A” uye mamwe gumi aine mazwi okuti “Boka B”.Mutori wechikamu mumwe nemumwe akakumbirwa kusarudza bepa rakapetwa kubva mubhokisi oripa kune rimwe remapoka maviri zvinoenderana.Nzira imwe cheteyo yakadzokororwa zvakare muboka rimwe nerimwe, ichigadzira rumwe rutivi rwemaxillary arch se "test" uye rutivi rwakapesana se "kutonga" mukugadzirwa kwemuromo.
Pamusoro pezvakajairika orthodontic zvinyorwa (intraoral uye extraoral mafoto, radiographs, uye mazino maratidziro), zvidzidzo zvakagadzirirwa zvakagadziriswa orthodontic kurapwa zvakanyoreswa nekunyora nhoroondo yavo yekurapa neyemazino.Varwere vakakumbirwawo kuita kuchenesa nemuromo kwakakwana uye kupukuta kunoteverwa nekuraira kwehutsanana hwemuromo (kushandiswa kwebhurashi remazino, floss uye interdental brushes).
Maxillary uye mandibular kugadzirisa newaya yakatwasuka Roth midziyo (Mini 2000; Ormco, USA) ine 0.022 ″\(\x)0.028″ slots yakagadziriswa muvarwere vese vakatorwa, uko maitiro ekugadzirisa akamisikidzwa kumapoka ese uye akatemerwa nemushandisi mumwechete..Zvadaro, murwere wacho akatumirwa kuti abudise maxillary first premolar kuti abvumire nguva yakakwana yokuti socket iporese mushure mekubviswa isati yatanga kubudiswa inenge mwedzi 2 mushure mekubudiswa.Kurongeka kunobva kwatanga uye kurongeka kwapera kana 0.016 ″ x 0.022 ″ waya yesimbi isina tsvina inogona kupinzwa mumazino ese maxillary.
Asati atanga kudzoreredza canine, epamusoro yechipiri premolars uye yekutanga molars zvakabatanidzwa pamwe ne 0.009-inch mufananidzo-sere waya pakuyedza nekudzora mativi emapoka maviri.Mukuwedzera, iyo maxillary incisors inosungirirwa pamwe chete nenzira imwecheteyo sechikamu chemashure kuti chibatsire kugadzikana uye kudzivirira kupatsanurwa kwavo.
Canine retraction mumapoka A uye B yakaitwa pachishandiswa nickel-titanium (NiTi) yakavharwa coil zvitubu (Ormco, USA), zvose pakuedza uye kudzora mativi, akatambanudzwa pakati hoko dzemabhuraketi canine uye zvikorekedzo pamusoro molar canal, ane simba 150 g inoyerwa dynamometer (Morelli, Brazil).
Diode laser (Wiser; Chiremba Smile-Lambda Spa, Brendol, Italy) yakashandiswa selaser-yakadzika-simba, ichiburitsa infrared mwaranzi ine wavelength ye980 nm uye inobuda simba re100 mW mune inoenderera modhi.A plane wave fiber (AB 2799; Chiremba Smile-Lambda Spa, Brendola, Italy) yakashandiswa kugovera 1 cm2 yedanda nzvimbo ine sandara pamusoro pemuromo, ichiisa iyo fiber tip parutivi rwemaxillary arch pakati pechitatu che maxilla.midzi ye canine padivi rekuedza (maererano nemirairo yemugadziri, zvishoma zvishoma 1.5 cm kana isina kutarisa) kwemasekonzi masere (Fig. 1).Iyo yakazara simba density yakashandiswa pachikamu chaive 8 J/cm2 (1 J/cm2 pasekondi).Iyo laser parameters inoshandiswa inoratidzwa muTebhenekeri 1. Kuchenjerera kwakatorwa musati mashandisa laser, uye vose murwere nemushandi vakashandisa magogi anopiwa nemuiti, zvichienderana newavelength inoshandiswa.
Iyo fiber tip yakabatwa chinhambwe che 1.5 cm kubva pamudzi weiyo maxillary canine padivi rekuyedza maererano nemirairo yemugadziri.
Iyo nzira yekuparadzanisa-muromo yakashandiswa mumapoka ese ari maviri, uye mumwe nemumwe anotora chikamu akaverengerwa kuti agamuchire LILI kune rumwe rutivi rwemaxillary arch uye kune rumwe rutivi sekutonga.Muboka A, zvidzidzo zvakagamuchira LILT pamazuva 0, 3, 7, 14 uyezve masvondo maviri ega ega, asi muboka B raishandiswa mavhiki ega e3 pachikamu chekuedza kwenguva yose yekudzidza (vhiki dze12) dzeLILT.Iyo laser beam yakange yakangomisikidzwawo padivi rekutonga remapoka maviri, ichipa placebo mhedzisiro sechikamu chemaitiro ekupofumadza varwere vakanyoresa.Pamusana pemamiriro ekupindira panguva ino, mufambisi haagoni kunyengedzwa.
Pamberi pemuenzaniso wekuunganidza, mativi ose maviri emaxillary canines akacheneswa nekotoni swabs, akaparadzaniswa neanozvitsigira retractor, kusveta, uye machira ekotoni, uye zvinyoro-nyoro mhepo-yakaomeswa kwe5 s.Samples dzakatorwa kubva kune distal clefts dzemaxillary canines uchishandisa yakajairwa sefa mapepa mitsetse (Whatman, Maidstone, UK) uye akachekwa kuita saizi yakaenzana ye2 × 10 mm2.Isa zvinyoro nyoro mutsara wega wega kusvika iwe uchinzwa kushomeka kushoma, wozoisiya munzvimbo kwemasekonzi makumi matanhatu uchichengeta chisimbiso chakakodzera (Mufananidzo 2).Mushure mekubviswa, mitsetse mitsva yakaiswa yega yega 1 min kuti iwane 4 mitsetse panzvimbo yega yega.Matanho akatorwawo kudzivirira kukuvadzwa kwemichina kune gingival fissure.Rasa sampuli dzakasvibiswa nemate kana ropa uye tora zvitsva.Mienzaniso yeGCF yakatorwa pakutanga (kusati kwatanga kudzoreredza canine), kubva kune distal canine fissures mumapoka A uye B, pamativi ekuyedza nekudzora, kunze kwemazuva 7, 14, uye 21.
Alginate impressions (Ca37; Cavex, Haarlem, The Netherlands) yakaitwa isati yasvika canine retraction uye yakadzokororwa masvondo ose e3 panguva yekudzidza kwevhiki ye12 pakushanya kwega kwega.Pakushanya kwega kwega, waya uye zvitubu zvekoiri zvaibviswa, maratidziro ealginate aitorwa, uye calculus yakakandirwa.Mutevedzeri wemazino wochekwa woiswa zita remurwere, nhamba uye zuva.Iyo plaster modhi yakabva yaongororwa (inEos X5 CAD/CAM laboratory scanner; Dentsply Sirona, PA, USA) kugadzira mufananidzo wedhijitari wemhando mitatu (3D) yemhando yezino.Izvo zviyero zvinodiwa zvakaitwa uchishandisa AutoCAD version 2013 (AutoCAD; Autodesk, USA).Vanachiremba vakanga vasingazivi nezvekuedza uye kudzora mativi panguva yezviyero zvekudzivisa kusarura kusinganzwisisike, uye intra-investigator kuvimbika cheki yakaitwa nekudzokororwa kuyerwa neanoshanda mumwechete vhiki gare gare kuti aongorore zvikanganiso zvekuyera.Iyo inofungidzirwa kuyerwa kukanganisa i6%.
Zviverengero zvakati wandei zvakawanikwa pane mazino akakanda, kusanganisira yepakati palatal suture, iyo yepakati mapoinzi ekuruboshwe nekurudyi petatu petatu, uye cusps yekuruboshwe nekurudyi maxillary canines.Mutsara wakatwasuka unomhanya kubva kupakati pepakati pekuruboshwe nekurudyi kwechitatu kupeta uye machubhu ekuruboshwe nekurudyi maxillary canines kuenda kumedian palatine suture.Anterior-posterior zviyero zvakatorwa pakati pemaviri canine line uye yechitatu peta mutsara kuti uongorore canine retraction (Figs. 3, 4).
Tsvaga nzvimbo dzakaiswa pamifananidzo yakaongororwa yemhando yemazino kuyera kubviswa kwe canine.(Poshi).Pakati palatal suture.(b, d).Tubercles yekuruboshwe uye kurudyi maxillary canines, zvichiteerana.(c, e).Mitsetse inoenderana nemukati migumo yechitatu kuruboshwe uye kurudyi kupeta, zvichiteerana.
Mushure mekubviswa kubva kune gingival crevice, mapoka mana emasefa mapepa akaunganidzwa munzvimbo imwechete akaiswa muEppendorf tubes (Capp, Denmark) ine 100 µl yephosphate-buffered saline.Eppendorf machubhu akavharwa uye akanyorwa uye samples dzakabva dzaiswa centrifuged pa3000 rpm kwemaminetsi gumi uchishandisa centrifuge (Hettich Universal 320R BC-HTX320; GMI, MN, USA) kudzoreredza maGCF samples kubva kumachira.Eppendorf machubhu akachengetwa pa -20 ° C kusvika biochemical analysis.Kuongororwa kwemazinga e-IL-1β kwakaitwa uchishandisa enzyme-yakabatanidzwa immunosorbent assay (ELISA; Cloud-Clone, Howe, USA).Iko kusanganiswa kweIL-1β kwakagadziriswa nekuenzanisa optical density (OD) yemasampuli akawanikwa ane chiyero chepamusoro uye zvichienderana nekuverenga equation yelinear regression of the standard curve.Pakupedzisira, mhedzisiro yeIL-1β mazinga anoratidzwa mu pg/ml/60 s25.Kuyerera kwemagadzirirwo echidzidzo kunoratidzwa muMufananidzo 5, unopfupikisa nzira yekudzidza.
Ongororo yenhamba yakaitwa pachishandiswa IBM SPSS yeWindows vhezheni 23.0 (IBM; Armonk, NY, USA).Zvose zvakasiyana-siyana zvehuwandu zvaiwanzogoverwa uye zvinoreva, kutsauka kwakajairwa (SD) uye 95% nguva yekuvimba (CI) yakaverengerwa uye bvunzo dzeparametric dzakashandiswa.Quantitative variables (canine retraction uye IL-1β level) yakaenzaniswa pakati pemapoka maviri ekudzidza achishandisa yakazvimiririra sampu t-test, nepo kuenzanisa pakati pelaser uye mativi ekudzora muboka rimwe nerimwe akaitwa achishandiswa paired t-bvunzo.Imbwa kudzosa uye IL-1β mazinga panguva dzakasiyana muboka rimwe nerimwe akafananidzwa zvakasiyana achishandisa akadzokororwa zviyero kuongororwa kwekusiyana kunoteverwa neakawanda pairwise kuenzanisa uchishandisa Bonferroni-yakagadziriswa kukosha mazinga. Kukosha kwakaiswa pa p value <0.05. Kukosha kwakaiswa pa p value <0.05. Значимость была установлена ​​при значении p <0,05. Kukosha kwakaiswa pa p value <0.05.显着性设定为p 值< 0.05.显着性设定为p值< 0.05. Значимость была установлена ​​на уровне p <0,05. Kukosha kwakaiswa pa p <0.05.
Munguva yekudzidza, hapana chidzidzo chakadonha kana panguva yepamberi yekupindira kana panguva yakasara yechidzidzo.Vese 20 vakatanga kutora zvidzidzo vakapedza iyo yose 12-vhiki yekudzidza nguva (10 zvidzidzo neboka).Kuyerera kwemurwere kwemuedzo wose kunoratidzwa muMufananidzo 6 uchishandisa CONSORT flowchart.Demographic data yezvidzidzo zvakanyoreswa muMapoka A uye B zvinoratidzwa muTebhu 2. Kwakange kusina zviitiko zvekuputika mumienzaniso yekudzidza, iyo yakaitwa mavhiki matatu ega ega kuyera canine retraction.Mukuwedzera, ese akagashira masampuli eGCM akanyatsogadziriswa uye akaongororwa.
Huwandu hwemaxillary canine retraction panguva dzakasiyana-siyana hunotsanangurwa muTebhurari 3, maererano nemapoka maviri A neB. MuBoka A, nhambwe yakakura kwazvo (± SD) inofambiswa nekanje huru yakashumwa pavhiki rechitatu kuve 1.18 (± 0.04) mm kudivi relaser, uye 0.85 (± 0.04 mutsauko wakakosha pakati pawo (± 0.04) 1). Huwandu hwemaxillary canine retraction panguva dzakasiyana-siyana hunotsanangurwa muTebhurari 3, maererano nemapoka maviri A neB. MuBoka A, nhambwe yakakura kwazvo (± SD) inofambiswa nekanje huru yakashumwa pavhiki rechitatu kuve 1.18 (± 0.04) mm kudivi relaser, uye 0.85 (± 0.04 mutsauko wakakosha pakati pawo (± 0.04) 1). Величина ретракции верхнечелюстного клыка в разные моменты времени описана в таблице 3 для обеих групп А и В.В группе А наибольшее среднее расстояние (± SD), пройденное верхнечелюстным клыком на 3-й неделе, составляет 1,18 (± 0,04 ± 0,04 с ,04) мм на стороне контроля, при этом разница между ними статистически значима (p < 0,001). Kuwanda kwekudzokororwa kwemaxillary canine panguva dzakasiyana-siyana kunotsanangurwa muTable 3 yemapoka maviri A uye B. Muboka A, kureba kureba kureba kureba (± SD) yaifambwa nemaxillary canine pavhiki 3 ndeye 1.18 (± 0.04) mm kudivi relaser uye 0.85 (± 0.04) mamirimita (0.0) mutsauko pakati pavo.Kumapoka A neB, dhigirii remaxillary canine retraction panguva dzakasiyana-siyana inotsanangurwa muTafura 3.在 A 组 中, 颌 颌 尖牙 移动 大 大 平均 平均 平均 平均 第 第 3 周 3在 第 3 周 移动 的 最 大 距离 距离 距离 在 第 3 周 报告 为 激光 侧 為 1.0 18 ± 1.04 () ± 8 mm . ± 0.04 mm有 具有 具有 具有 具有 具有 具有 具有统计学意义（p <0.001）. В группе А максимальное среднее расстояние (± SD) движения клыков верхней челюсти на 3-й неделе составило 1,18 (± 0,04) мм , 1, 18 (± 0,04) мм , 1, 18 (± 0,18) м на стороне контроля, разница между ними была Статистическая значимость (p <0,001). Muboka A, iyo yakanyanya kureba kureba (± SD) yemaxillary canine kufamba pavhiki 3 yaive 1.18 (± 0.04) mm padivi relaser uye 0.85 (± 0.04) mm padivi rekutonga, mutsauko uripo pakati pavo waive wakakosha (p <0.001). Nekudaro, huwandu hwekufamba kwezino hwakadzikira pasvondo rechitanhatu pane ese laser uye mativi ekudzora, ndokuzowedzera zvishoma nezvishoma mushure memavhiki mapfumbamwe negumi nemaviri, nehuwandu hwekufamba kwezino huchikwira zvakanyanya padivi relaser kana tichienzanisa nedivi rekutonga (p <0.001), panguva dzese dzenguva. Nekudaro, huwandu hwekufamba kwezino hwakadzikira pasvondo rechitanhatu pane ese laser uye mativi ekudzora, ndokuzowedzera zvishoma nezvishoma mushure memavhiki mapfumbamwe negumi nemaviri, nehuwandu hwekufamba kwezino huchikwira zvakanyanya padivi relaser kana tichienzanisa nedivi rekutonga (p <0.001), panguva dzese dzenguva.Nekudaro, iyo inorehwa huwandu hwekudzimisa mazino yakadzikira pavhiki 6 pane ese laser uye kudzora mativi, uyezve zvishoma nezvishoma yakawedzera mukati memavhiki 9 ne12, nehuwandu hwekubviswa kwezino zvakanyanya padivi re laser.laser kana ichienzaniswa neboka rekutonga.стороны (p < 0,001) во все моменты времени. divi (p <0.001) nguva dzese.然而，激光侧和对照侧的平均牙齿移动量在6 周下降，然后在第9 周和第12 周希希帎掌杀激光侧的牙齿移动量明显更高侧（p < 0.001），在所有时间点.然而 , 激光 和 对照侧的 牙齿 移动量 在 第 6 周 下降增加 , 与 对照 相比 , 的 移动量 明显 更 高侧 （p <0.001），在所有时间点. Однако среднее количество движений зубов на стороне лазера и контрольной стороне уменьшилось 6-й неделе, а затем постепененно увели12 , 9 движений зубов на стороне лазера было значительно выше по сравнению с контрольной стороной (p <0,001) во все моменты времени. Nekudaro, iyo inorehwa nhamba yekufamba kwezino padivi relaser uye yekudzora divi yakadzikira pavhiki 6 uyezve zvishoma nezvishoma yakawedzera mushure me9 uye 12 mavhiki, uye huwandu hwemazino emazino padivi re laser hwakanga hwakanyanya kukwirira zvichienzaniswa nedivi rekutonga (p <0.001) panguva dzese panguva. Huwandu hwekufamba kwezino (± SD) pamusoro peiyo 12-vhiki yekudzidza nguva yaive yakakwira zvakanyanya padivi relaser ne4.45 (± 0.13) mm, zvichienzaniswa neiyo padivi rekutonga raive 3.16 (± 0.14) mm (p <0.001). Huwandu hwekufamba kwezino (± SD) pamusoro peiyo 12-vhiki yekudzidza nguva yaive yakakwira zvakanyanya padivi relaser ne4.45 (± 0.13) mm, zvichienzaniswa neiyo padivi rekutonga raive 3.16 (± 0.14) mm (p <0.001). Общая величина смещения зубов (± SD) за 12-недельный период исследования была значительно выше на стороне зубов (± SD) 12-недельный период исследования была значительно выше на стороне лазера – 4,45 (± 0, 5) роной, которая составляла 3,16 (± 0,14) мм (p < 0,001). Huwandu hwese hwekubviswa kwezino (± SD) pamusoro peiyo 12-vhiki yekudzidza nguva yaive yakakwira zvakanyanya padivi relaser, 4.45 (± 0.13) mm, zvichienzaniswa nedivi rekutonga, iro raive 3.16 (± 0.14) mm (p <0.001).在為期12 周的研究期间，激光侧的牙齿移动总量(± SD) 显着更高，為4.45 (± 0.13) mm，而对0 (3.4) mm，而对0 (30.1 mm) mm，而对0 (30.1 mm). 1).在为期12 周的研究期间，激光侧的牙齿的牙齿纻动总量(± SD) 显着更高，為4.45 (± 0.30平) ± 0.30 16 (± 0.301) ± 0.30 16 mm (± 0.16) (± 0.16) (± 0.16 (± 0.16) (± 0.16) (± 0.16) В течение 12-недельного периода исследования общее перемещение зубов (± SD) было значительно выше на стороне лазера и соста, 475 ± 3 соста, 4 м ,16 (± 0,14) мм в контрольной группе (p < 0,001). Munguva ye12-vhiki yekudzidza nguva, kufamba kwezino rose (± SD) kwaive kwakakwira zvakanyanya padivi relaser pa4.45 (± 0.13) mm zvichienzaniswa ne3.16 (± 0.14) mm muboka rekutonga (p <0.001).
MuBoka B, muenzaniso wakafanana newakaratidzwa muBoka A wakateverwa, uine hutsika hwakanyanya hwepamusoro hwekufamba kwezino kunyorwa padivi relaser, mukuenzanisa nedivi rekutonga panguva dzese dzenguva (p <0.001). MuBoka B, maitiro akafanana neakaratidzwa muBoka A akateedzerwa, aine hukuru hwakanyanya hwekufamba kwemazino achirekodhwa padivi relaser, mukuenzanisa nedivi rekutonga panguva dzese dzenguva (p <0.001). В группе B наблюдалась аналогичная картина, продемонстрированная в группе A, со значительно более высокими значениями для в группе. все моменты времени (p <0,001). Boka B rakaratidza chimiro chakafanana neBoka A, chine akanyanya kukwirira mazino mafambiro akanyorwa padivi relaser zvichienzaniswa nedivi rekutonga nguva dzese (p <0.001).20 ）. <0.00 В группе B, по аналогии с группой A, зарегистрированные значения перемещения зубов были значительно выше на группой A, зарегистрированные значения перемещения зубов были значительно выше на стороне менты времени (p <0,001). Muboka B, rakafanana neboka A, marekodhi akarekodhwa ekufamba kwezino aive akakwira zvakanyanya padivi relaser zvichienzaniswa nedivi rekutonga nguva dzese (p <0.001).Mushure memavhiki e3, kufamba kwemazino kwakanyanya (± SD) kwakanyorwa nehuwandu hwe1.14 (± 0.04) mm padivi re laser uye 0.87 (± 0.03) mm padivi rekutonga.Kufamba kwezino kwakazodzikira pavhiki 6 uyezve kwakawedzera zvishoma nezvishoma. Huwandu hwese hwe canine retraction (± SD) pamusoro peiyo 12-vhiki yekudzidza nguva palaser uye mativi ekutonga, yaive 4.35 (± 0.12) mm, uye 3.10 (± 0.06) mm, zvichiteerana, uye mutsauko uripo pakati pawo wakakosha zvakanyanya (p <0.001). Huwandu hwese hwe canine retraction (± SD) pamusoro peiyo 12-vhiki yekudzidza nguva palaser uye mativi ekutonga, yaive 4.35 (± 0.12) mm, uye 3.10 (± 0.06) mm, zvichiteerana, uye mutsauko uripo pakati pawo wakakosha zvakanyanya (p <0.001).Iyo yakazara canine kudzoreredza (± SD) pamusoro pegumi nemaviri-vhiki yekudzidza palaser uye mativi ekudzora yaive 4.35 (± 0.12) mm uye 3.10 (± 0.06) mm, zvichiteerana, uye mutsauko uripo pakati pawo wakanyanya kukosha.(р <0,001). (p <0.001).在為期12 周的研究期间，激光侧和对照侧的犬齿回缩总量(± SD) 分别為4.35 (± 0.12) ± 0.12) mm ± 0.12) mm ± 3.10 (6.异具有统计学意义(p <0.001).在 为期 12 周 的 研究 ， 激光 侧 和 对照侧 的 回缩 总量 总量 总量 (± sd) ± 3 sd) ± 30 ± 3 ± 2 (3 mm) ± 2 (30) (30) (3 mm 4) (30 . mm , 之间 的 差异 具有 统计学 意义 (p <0.001). В течение 12-недельного периода исследования общая (± SD) ретракция клыка на стороне лазера и контрольной стороне составила 4,35 (± 10, ± 10, ± 10, ± 10, ± 10), ответственно, и разница была статистически значимой (p <0,001). Munguva ye12-vhiki yekudzidza nguva, yakazara (± SD) canine kudzoreredza padivi relaser uye control side yaive 4.35 (± 0.12) mm uye 3.10 (± 0.06) mm, zvichiteerana, uye mutsauko waive wakakosha (p <0.001). .Tafura 4 inotsanangura kufananidzwa kwedhigirii rekurumwa kwecanine panguva dzakasiyana dzenguva pakati pelaser nedivi rekutonga muboka rega rega rekudzidza.
Kunyange zvazvo dhigirii ye canine retraction ne laser yakanga yakakwirira muboka A kupfuura muboka B panguva dzose dzenguva, musiyano uyu hauna kuonekwa sehuwandu hunofananidzwa neboka B (p = 0.08-0.55).Nezvekuwedzerwa kwezana (± SD) mu canine retraction inowanikwa neprotocol imwe neimwe, protocol inoshandiswa muboka A yakawedzera ne 40.78 (± 4.81)%, nepo protocol inoshandiswa muboka A yakawedzera ne 40 .22 (± 4.80)% muboka B. laser application protocol yakagamuchirwa.Zvakadaro, kunyangwe chikamu ichi chaive chakakwira zvishoma muboka A pane muboka B, mutsauko uripo pakati pavo wakanga usina kukosha (p = 0.82).Mukuwedzera, zvakaonekwa kuti chimiro chekufamba kwemeno mumapoka ose ari maviri akafanana (Fig. 7).
Laser retraction ye lateral canine (mm) panguva dzakasiyana-siyana mumapoka maviri ekudzidza panguva ye12-vhiki yekudzidza.
Tafura 5 inotsanangura mazinga e IL-1β mumapoka A uye B panguva yose yakayerwa nguva pa laser uye kutonga mativi.Muboka A, mutsauko uripo pakati pelaser side nedivi rekutonga pakutanga wanga usina kukosha kune IL-1β kukosha (p = 0.56). Chiyero chepamusoro-soro cheIL-1β (± SD) chakanyorwa pazuva rechinomwe pamativi ese ari maviri laser uye kudzora, nemitengo ye0.152 (± 0.004) pg/ml/60 s, uye 0.127 (± 0.004) pg/ml/60 s, zvichiteerana, uye 0. Iyo yepamusoro-soro nhanho yeIL-1β (± SD) yakanyorwa pazuva rechinomwe pamativi ese ari maviri laser uye ekudzora, ine makoshero e0.152 (± 0.004) pg/ml/60 s, uye 0.127 (± 0.004) pg/ml/60 s, zvichiteerana, uye 0.0 musiyano wakakosha pakati pavo.Iyo yepamusoro-soro nhanho yeIL-1β (± SD) yakanyorwa pazuva rechinomwe pane ese laser uye kudzora mativi ane kukosha kwe0.152 (± 0.004) pg/mL/60 s uye 0.127 (± 0.004) pg/mL./60 соответственно, а разница между ними была статистически значимой (p <0,001). / 60 s, zvichiteerana, uye mutsauko pakati pavo waive wakakosha (p <0.001).在第7 天，激光侧和对照侧均记录到最高水平的IL-1β (± SD)，值為0.152 (± 0.004) pg/ml/60 s 和0.0g/s p/s 60 s 和0.0g/s/s 60 s 和0.0g/s/60 s 3.0g/s/60 s 和0.0g/s.之间的差异具有统计学意义（p <0.001）.在第7 天，激光侧和对照侧均记录到最高水平的IL-1β (± SD)，值为0.152 (± 0.004) pg/ml/60 s 和 0.0g120ml/60 s 和 0.0g/4 p. ）.Pazuva rechinomwe, iwo epamusoro mazinga eIL-1β (± SD) akarekodhwa pane ese ari maviri laser uye ekudzora mativi ane kukosha kwe0.152 (± 0.004) pg/mL/60 s uye 0.127 (± 0.004) pg/mL./60 p.Разница между ними была статистически значимой (p <0,001). Musiyano pakati pavo waive wakakosha (p <0.001). Kudzikira zvishoma nezvishoma mumazinga eIL-1β kwakazotaurwa ipapo, pamazuva 14 uye 21, pane ese ari maviri laser uye mativi ekutonga, nehukoshi padivi relaser huchikwira zvakanyanya kupfuura izvo zviri padivi rekutonga (p <0.001). Kudzikira zvishoma nezvishoma mumazinga eIL-1β kwakazotaurwa ipapo, pamazuva 14 ne21, pane ese ari maviri laser uye mativi ekutonga, nemakoshero ari padivi relaser achikwira zvakanyanya kupfuura ayo ari padivi rekutonga (p <0.001). Восле этого сообщалось остепенном уровней IL-1β pa 14 uye 21 mazuva как на стороне лазера, так и на стороне контролья, пристание на земли тельно выше, чем на стороне контроля (p <0,001). Pashure pacho, kuderera zvishoma nezvishoma mumazinga eIL-1β kwakashumwa pamazuva 14 uye 21 pane ese laser uye mativi ekutonga, aine hutsika padivi relaser achikwira zvakanyanya kupfuura ayo ari padivi rekutonga (p <0.001). .此后，在第14 天和第21 天，激光和对照侧的IL-1β 水平逐渐下降，激光侧的值显着高于对 <0 .此后，在第14 天和第21 天，激光和对照侧的IL-1β 水平逐渐下降，激光侧的值显着高于对 После этого 14-й 21 й дни уровни ИЛ-1β постепенно на стороне лазера и в контроле, при этом значения на сторонее на бесплатно. контроля (p <0,001). Mushure meizvozvo, pamazuva gumi nemana uye 21st, mazinga eIL-1β akadzikira zvishoma nezvishoma padivi relaser uye mukutonga, nepo hunhu padivi relaser hwaive hwakanyanya kukwirira kupfuura kudivi rekutonga (p <0.001).
Muboka B, muenzaniso wakafanana wakaonekwa muboka A maererano nemazinga e-IL-1β, ane misiyano miduku yakaonekwa pakutanga pakati pe laser uye mativi ekutonga (p = 0.02). Mushure memazuva manomwe, nhongonya yeIL-1β level (± SD) yakasvikwa kumativi ese, ne0.139 (± 0.004) pg/ml/60 s padivi relaser, uye 0.122 (± 0.003) pg/ml/60 s padivi rekutonga, ine ma values ​​ari padanho repamusoro 0.0. Mushure memazuva manomwe, nhongonya yeIL-1β level (± SD) yakasvikwa pamativi ese, paine 0.139 (± 0.004) pg/ml/60 s padivi relaser, uye 0.122 (± 0.003) pg/ml/60 s padivi rekutonga, ine ma values ​​ari 0.Mushure memazuva manomwe, peak level yeIL-1β (± standard deviation) yakasvikwa pamativi ese: 0.139 (± 0.004) pg/ml/60 s padivi relaser uye 0.122 (± 0.003) pg/ml/60 s.на контрольной стороне, при этом значения на стороне лазера считались статистически более высокими (p <0,001). padivi rekutonga, nepo hunhu padivi relaser hwaionekwa sehuwandu hwepamusoro (p <0.001). 7天后，两侧达到IL-1β水平峰值（±SD），激光侧為0.139（±0.004）pg/ml/60 s，激光侧為0.100p/s/ml/60 激光侧為0.100p/m/s/m.制侧，激光侧的值在统计上更高（p <0.001）. 7 天 后 , 两 侧 达到 达到 il-1β 水平 (（±） , 激光 侧 為 為 0.139 ± 0.004） pg/ml/ml/6). ,值在统计上更高 (p <0.001).Mushure memazuva manomwe, mazinga epamusoro eIL-1β (± SD) akawanikwa kumativi ose maviri: 0.139 (± 0.004) pg/ml/60 s padivi relaser uye 0.122 (± 0.003) pg/ml/60 s padivi rekutonga., лазер Значения на стороне были статистически выше (p < 0,001). , Laser Values ​​padivi yaive yakakwira zvakanyanya (p <0.001).IL-1β mazinga akazoderera zvishoma nezvishoma kumativi ose pamazuva 14 uye 21, uye mazinga akanyorwa pa-laser side akanga akakwirira zvikuru achienzaniswa nedivi rekutonga panguva dzose dzenguva (p = 0.001-0.002).Kuenzanisa kwemazinga eIL-1β panguva dzakasiyana-siyana pakati pe laser side uye rutivi rwekutonga muboka rega rega rekudzidza rinotsanangurwa muTebhu 6.
Kana uchienzanisa mazinga e-IL-1β pakati pemapoka maviri ekudzidza, kusiyana kusingakoshi kwakanyorwa padivi re laser pane yekutanga (p = 0.96). Pazuva rechinomwe neregumi nemana, mutsauko wakakosha wakanyoreswa pakati pemativi emalaser mumapoka ese, aine hunhu hwepamusoro hwemativi e laser muBoka A (p <0.001). Pazuva rechinomwe nerechigumi nemana, misiyano yakakura yakanyoreswa pakati pema laser mativi mumapoka ese ari maviri, aine hunhu hwepamusoro hwemativi e laser muBoka A (p <0.001). 7-й uye 14-й дни зарегистрированы статистически значимые различия между лазерными сторонами в обеих группах, причемы болезе в обеих группах. ным сторонам в группе А (р < 0,001). Pamazuva 7 ne14, pakanga paine misiyano yakakosha pakati pema laser mativi mumapoka ese ari maviri, aine hunhu hwepamusoro hwema laser mativi muboka A (p <0.001).在第7 天和第14 天，两组激光侧的差异有统计学意义，A 组激光侧的值较高（p <0.001）. A На 7 uye 14 дни разница между двумя группами была статистически значимой на стороне лазера с более высокими значениями на стопроне 10 (10). Pamazuva 7 ne14, mutsauko pakati pemapoka maviri aya waive wakakosha padivi relaser, uine hunhu hwepamusoro padivi relaser muboka A (p <0.001).Mushure memazuva makumi maviri nerimwe, pakanga pasina musiyano mukuru pakati pemapoka maviri (p = 0.26).Mazinga e-IL-1β mumapoka maviri aiva nechimiro chakafanana, anosvika pakakwirira pazuva re7 uye zvishoma nezvishoma achiderera pa14th uye 21st mazuva (Fig. 8).
Chinangwa chechidzidzo ichi chaiva chekuongorora uye kuenzanisa kuitika kweLILR pakugadzirisa canine uchishandisa protocol inosanganisira high frequency laser irradiation pamazuva 0, 3, 7, 14 uye mavhiki maviri ega ega (Group A) nevarwere vachangobva kupinda.pakanga pane zviyeuchidzo zvishoma zvichienzaniswa nehurongwa umo laser exposure yakaitwa panguva dze3-vhiki dzevhiki (boka B).Ingave iri general high frequency protocol7,13,26 kana 3-vhiki protocol15,17,18, maprotocol ese ari maviri anotsanangurwa mumabhuku.Kubva pamigumisiro yakaratidzwa muchidzidzo chezvino, null hypothesis haina kurambwa, uye kuburikidza nekushandiswa kwezvibvumirano zviviri zvakadzidzwa, nhamba dzakaenzana dzekufamba kwembwa dzakawanikwa.
Ikozvino kudzidza dhizaini ikiriniki randomized controlled trial (RCT).RCTs inoonekwa seyegoridhe chiyero chekuongorora mhedzisiro yekupindira27.Nzira yekuparadzanisa-muromo yakashandiswawo, iyo inonyanya kukosha ndeyokuti kusiyana-siyana kwezvidzidzo kunobviswa, nemurwere mumwe nomumwe achiita semutongi wavo, nokudaro kuderedza nhamba yevatori vechikamu inodiwa.
Zvose zvidzidzo zvakabatanidzwa muchidzidzo zvaida kubudiswa kwe maxillary first premolar inoteverwa ne canine retraction sechikamu chekurapa orthodontic.Sezvo kubviswa kunogona kuchinja chiyero cheRTM nekuwedzera basa rezvipembenene zvinopisa, izvo zvinogona kuvharidzira kuitika kweLILT uye kupa kuverenga kwenhema kwemazinga e-IL-1β pakushandisa laser, kurapwa kwekutsvaga kwakaitwa kusati kwaitwa kurapwa, izvo zvakapa chigumisiro chakanaka.Healing socket extraction solution inopa nguva yakakwana uye inokunda mhedzisiro yedunhu rekukurumidza phenomena28.Iyi kuchenjerera yakatorwawo nevamwe vanyori, 11 avo vakatsvaga mhedzisiro yeLILT pachiyero cheOTM panguva yekudzoreredzwa mumbwa nekuyera mazinga ezvinyorwa zvebiomarkers seIL-1β uye kushandura kukura factor β1 (TGF-β1) muGCF.
Mhando yelaser yakashandiswa muchidzidzo ichi yaive diode semiconductor laser yakashandiswa pa980 nm zvichienderana nekurudziro yemugadziri weiyo optimal biostimulation.Izvi zvinogona kutsanangurwa nenyaya yekuti iyo yakareba laser wavelength (650-1200 nm), iyo yakadzama iyo tishu inopinda29.Nekudaro, iyi yakakurudzirwa wavelength yakashandiswa mune zvimwe zvidzidzo zvakati wandei, ichigadzira yakanaka kukurumidza mhedzisiro ye8.30 uye yakaipa mhedzisiro ye14.
Chimwe chinhu chakakosha chinokonzera kushanda kweLILI kurapwa uye biostimulation ndeyeyero kana simba density.Pakuwongorora zvinyorwa, zvakaonekwa kuti kune yakakura heterogeneity muyero yeLILI simba kuti ikurumidze iyo GTM.Vamwe vanyori vanotaura mhedzisiro yakanaka kana vachishandisa yakaderera simba densities kubva 0.7131, 532.33, 7.514 kusvika 8 J/cm234.35, nepo vamwe vaongorori vanorondedzerawo mhedzisiro yeLILR pachiyero cheGTM pane yakakwira simba densities, semuenzaniso, 25 J/cm2.cm27.36.Mubasa razvino, muyero weyero yakaderera laser simba ye8 J/cm2 yakaunzwa nekuratidzwa kamwe chete kune maxillary canine midzi kwemasekonzi masere uchishandisa yakatsetseka kumusoro muromo kugovera danda nzvimbo ye1 cm2.Pane kuwirirana kwakananga pakati pehukuru hwedanda nekudzika kwekupinza kwelaser, izvo zvinozopa chikonzero chekushandiswa kwemachira epamusoro emaoko muchidzidzo chino29,37.Iyo imwechete application protocol ine yakakura danda nzvimbo saizi inoitwa nekurongeka uye kurongeka 8 uye canine retraction 38.
IL-1β inozivikanwa kuva yakakosha pro-inflammatory cytokine pakutanga kweOTM uye inoonekwa sechiratidzo chepfupa resorption.Nokudaro, mazinga e-IL-1β akaongororwa ne laser mune zvidzidzo zvakawanda11,39,40 mukuedza kuziva kuwirirana kwavo.Muchiyedzo chazvino, IL-1β mazinga muGCF akaongororwa pamativi ekuyedza nekudzora eboka rega rega nekushandisa maviri akasiyana regimens eLILI pamazuva 0, 7, 14, uye 21.
Muchidzidzo chemazuva ano, canine retraction ne laser mumapoka A uye B akanga akakwirira zvikuru kupfuura muboka rekutonga panguva dzose pfungwa dzakaongororwa, dzichikwira pavhiki 3, dzichiderera kwevhiki imwe chete pavhiki 6, uye zvishoma nezvishoma kuwedzera kusvika kuvhiki 12..Peak canine movement inoonekwa pavhiki 3 inogona kutsanangurwa nemigumisiro yekutanga mazino ekudzimisa, kusanganisira: midzi yekuchinja muPDL, kuputika kwepfupa nekuda kwekushanduka uye kukambaira, uye kudzvinyirira kudzvinyirira kwezino nekuda kwekuda kweiyo conical socket Plane effect 41. Mukuwedzera, zvakaonekwa kuti zvose zvinoshingaira zvipenyu zvipenyu zvinoramba zvichikurumidza kukurumidza kukurumidza kuputika.Kunonoka kunotevera kunoonekwa pakati pe3 nemavhiki matanhatu, zvichida nekuda kwekunonoka kwenguva inogona kusiyana kubva ku2 kusvika kumavhiki e10, inguva yekuvhiringidza kwePDL iyo inogadzirisa uye inobvisa pfupa riri pedyo nenzvimbo yakapwanyika, zvichibvumira kufamba kwepfupa.mazino.Chimwe chinhu chinokonzera kucherechedzwa uku chingave chekuti oxygenated fibers, collagen fibers, uye alveolar bone remodeling parutivi rwekunetsekana kunogonawo kuderedza chiyero chekufamba kwezino.Mamiriro akafanana ekufamba kwezino akawanikwa mune cleft study45 achienzanisa migumisiro yeLILI uye corticotomy pa canine retraction rate, vakacherechedza kuti kufamba kwezino kwaiva kukuru pavhiki 2 ne5, zvichiteverwa nekuderera kwakanyanya pa2 uye 5 vhiki.vhiki.Izvi hazvina kutaurwa padivi relaser pavhiki 7, asi kwete kudivi recorticotomy.
Iyo yakashumwa inoreva kuwedzera kwehuwandu hwehuwandu hwekufamba kwekufamba kwema maxillary canine kubva kune rumwe rutivi rwe laser yaiva 40.78% muboka A uye 40.22% muboka B. Kuwedzera kunoratidzika mukufamba kwezino kunofambidzana nekushandiswa kwe laser kunogona kutsanangurwa pachiyero chemasero kuburikidza nekutora kwelaser simba ne photoreceptors mukati meketani-electronto yekufambisa mukati meketani-electronto.Izvi zvinotungamirira kunguva pfupi kushandiswa kweketani yekufema, iyo inotungamira kune oxidative phosphorylation uye kuchinja mune redox mamiriro e cellular mitochondria uye cytoplasm.Zvakare, simba rekutyaira resero rinowedzerwa nekuwedzera kupihwa kweATP.Mukuwedzera, kune kuwedzera kwekugona kweiyo mitochondrial membrane, alkalization ye cytoplasm, uye synthesis ye nucleic acids.Sezvo ATP ichizivikanwa semari yesimba remasero, LILI inobatsira mukushanda kwakajairika kwemasero nekugadzira nharaunda yakanaka yekufamba kwezino46.Nokudaro, kubva pamigumisiro yedu, tinogona kugumisa kuti kushandiswa kweLILT sechigadziro kune orthodontic kurapwa kunogona kubudirira kukurumidza OTM pasinei nokuti inoshandiswa kakawanda sechirongwa cheboka A (pamazuva 0, 3, 7, 14 uye zuva rega rega).mushure memazuva maviri) mavhiki), kana kuti kana yakashandiswa zvishoma muboka B (masvondo ega ega e3), saka, null hypothesis haina kurambwa.
Izvo zvakafanana zvinokurumidza kukurumidza mhedzisiro yezviviri zvakaedzwa LILT maprotocol akataurwa muchidzidzo ichi zvinogona kunge zvakakonzerwa nekuvapo kweserura activation chikumbaridzo apo yakawedzera cellular activation neLILT exposure inoitika pakutanga, asi yozodzokororwa kuratidzwa (sezviri muboka A), nekuda kwekuzara kwebiological reactions hazvizokonzerese kuenderera mberi.Nekudaro, isu tinogona kufunga kuti mhedzisiro yeLLLT padanho reserura haigone kuwedzera.Nezve hukama pakati pesimba rekumanikidza uye kumhanya kwemeno, iyo pfungwa ye biosaturation yakatsanangurwa kare.
Mushure mekuongorora zvinyorwa zviripo, takafananidza kuwedzera kwe1.4-fold (40-41%) muWTM yakawanikwa muchidzidzo chedu tichishandisa maviri laser protocol nemhedzisiro yemamwe mishumo yakati wandei.Zvimwe zvidzidzo zvakataura zvakafanana mhedzisiro11,30,48,49 nepo vamwe vakashuma zvishoma kuderera kukwidziridza kukosha kwakashandiswa uchishandisa LILI7,18,32,40.Nekune rumwe rutivi, yakanyanya kukwirira kukwirisa ukoshi pane izvo zvinoshumwa mukuyedzwa kwazvino, kubva ku1.65 × 17 kusvika kune inenge 2x OTM15, 34, 39, 50, iyo inogona kunge ine hukama kune dzimwe dzadzo Shandisa mabhureki ekuzvivharira pasina friction 15. Musiyano uyu mumhedzisiro inoburitswa mumabhuku inogona kunge yakakonzerwa neyakasiyana-siyana yenguva yekurapa, maratidziro emagetsi ekushandisa, kurapa kwakasiyana-siyana laser, nezvimwewo. ., izvo zvinoita kuti kuenzanisa kwakananga pakati pezvidzidzo zvakasiyana kuve kwakaoma..Zvakadaro, zvakacherechedzwa kuti kuderera kwesimba remagetsi (eg 2.5, 5 uye 8 J/cm2) inopa zvirinani kukurumidza kukurumidza kana zvichienzaniswa nepamusoro pesimba remagetsi, zvakakosha kuziva kuti madhasi akashandiswa mukuedza kwedu aive 8 J/cm2.cm2.
Kududzirwa kwemazinga e-IL-1β mu distal cleft (compression side) mushure mekuongororwa kwezviwanikwa zveGCF zvakawanikwa zvakaratidza kuwedzera kwenhamba kubva kune yekutanga (kureva peak) pazuva re7 rinoteverwa nekuderera zvishoma nezvishoma kusvika kune yekutanga.pamapanera A uye B, padivi relaser uye padivi rekutonga.Izvi zvinogona kutsanangurwa nenyaya yekuti chikamu chekutanga cheOTM chinowanzoperekedzwa nekuwedzera kwekuita osteoclast.IL-1β inoonekwawo seyokutanga kuoneka mucherechedzo wakabatana nefupa resorption, uye IL-1β kutaura kwakanzi kunowedzera nesimba uye kuderera muzvidzidzo zvakawanda11,20,51.
Mukuwedzera, mazinga e-IL-1β akanga akakwirira padivi re laser kana achienzaniswa neboka rekutonga mumapoka ose ekudzidza panguva dzose dzakayerwa nguva kunze kwekutanga, uye pakanga pane mutsauko wakakosha pakati pavo.Izvi zvinoratidza kuti low-intensity laser irradiation yakakonzera kukwidziridzwa kwebiological mhinduro mu periodontal tishu padivi rekuyedza nenzira yekukurudzira osteoclast basa padivi rakamanikidzwa panguva ye orthodontic mazino kufamba.Izvi zvinokonzerwa neLLLT pamazinga e-IL-1β zvakaratidzwa mune zvidzidzo zvakasiyana-siyana11,39,40.
Pakufananidza laser-side IL-1β mazinga mumapoka maviri ekudzidza, mazinga aive akakwirira muboka A kana achienzaniswa neboka B pamazuva 7 uye 14. Izvi zvinogona kutsanangurwa nehuwandu hwehuwandu hwekutsvaga laser irradiation muboka A panguva yekucherechedza kwemazuva 21, apo irradiation yakaitwa pamazuva 0, 3, 7, uye kupfurwa kwezuva 1, 14, uye 14 chete, uye kupfurwa kwe14, uye pfuti ye14, B. β mazinga aive akakwira zvakanyanya padivi relaser muboka A, mutsauko wenhamba uyu hauna kuratidzwa nekiriniki muchiyero chekudzoreredza mumbwa zvichienzaniswa nedivi relaser muboka B, sezvo pakanga pasina kukosha kwenhamba.Mumapoka A neB, misiyano yakashumwa mukudzokororwa kwecanine pakati pelaser mativi zvakakonzera huwandu hwakafanana hwekufamba kwembwa.Nokudaro, tinogona kutaura kuti kusiyana kwenhamba hakurevi kutsanangura kukosha kwekliniki.
Low-intensity laser therapy, kana yakashandiswa nemiganhu inoshandiswa muchidzidzo ichi, inogona kukurumidza kukurumidza kufamba kwemazino e orthodontic neanenge 1.4 nguva, ingave inoshandiswa pamwero wepamusoro kana wakaderera, uchienderana nekutevera nguva dzose, zvichida.zvakanyanya kufanirwa nevarwere.
Kuwedzera kwe orthodontic mazino kufamba panguva yeLILI kwaifambidzana nekuwedzera kwezinga re interleukin-1β padivi rakamanikidzwa, iro rinoratidza kuti kushandiswa kweLILI kunokonzera kusimbiswa kwekugadzirisa pfupa.
Iwo madhata akashandiswa uye/kana akaongororwa muchidzidzo chazvino anowanikwa kubva kuvanyori vakasiyana pakukumbira zvine musoro.
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