Lub siab purity pob valve yog dab tsi? Lub Siab Purity Pob Valve yog cov khoom siv tswj kev khiav dej num uas ua tau raws li cov qauv kev lag luam rau cov khoom siv thiab tsim purity.Valves nyob rau hauv cov txheej txheem siab purity yog siv nyob rau hauv ob qhov loj ntawm daim ntawv thov:
Cov no yog siv rau hauv "kev txhawb nqa" xws li kev ua haujlwm tu chav rau kev ntxuav thiab tswj qhov kub thiab txias.Hauv kev lag luam kws tshuaj, pob li qub yeej tsis siv rau hauv daim ntawv thov lossis cov txheej txheem uas tuaj yeem cuam tshuam ncaj qha nrog cov khoom kawg.
Cov txheej txheem kev lag luam rau siab purity li qub yog dab tsi? Kev lag luam kws tshuaj muab cov qauv xaiv valve los ntawm ob qhov chaw:
ASME / BPE-1997 yog cov ntaub ntawv hloov pauv uas hais txog kev tsim thiab siv cov khoom siv hauv kev lag luam kws tshuaj.Qhov qauv no yog tsim rau kev tsim, khoom siv, kev tsim kho, tshuaj xyuas thiab kuaj cov hlab ntsha, cov kav dej thiab lwm yam khoom siv xws li twj tso kua mis, li qub thiab fittings siv hauv kev lag luam biopharmaceutical. Qhov tseem ceeb, cov ntaub ntawv sib cuag nrog cov khoom lag luam los yog cov khoom lag luam, ... manufacturing, txheej txheem kev loj hlob los yog scale-up ... thiab yog ib feem tseem ceeb ntawm cov khoom tsim, xws li dej rau txhaj tshuaj (WFI), huv chav, ultrafiltration, intermediate khoom cia thiab centrifuges. "
Niaj hnub no, kev lag luam tso siab rau ASME / BPE-1997 los txiav txim siab lub pob valve tsim rau cov ntawv thov kev sib cuag uas tsis yog khoom.Cov cheeb tsam tseem ceeb ntawm cov kev qhia tshwj xeeb yog:
Cov li qub feem ntau siv hauv cov txheej txheem biopharmaceutical muaj xws li pob li qub, diaphragm li qub, thiab kos li qub.Cov ntaub ntawv engineering no yuav txwv rau kev sib tham ntawm pob li qub.
Validation yog ib tug txheej txheem tswj tsim los xyuas kom meej lub reproducibility ntawm ib tug txheej txheem cov khoom los yog formulation.Qhov kev pab cuam qhia los ntsuas thiab saib xyuas txhua yam txheej txheem Cheebtsam, formulation lub sij hawm, kub, siab thiab lwm yam tej yam kev mob.Thaum ib tug system thiab cov khoom ntawm lub system yog proven rov ua dua, tag nrho cov Cheebtsam thiab tej yam kev mob raug xam tias yog validated.No hloov tej zaum yuav ua rau qhov kawg "pob" (tsis muaj txheej txheem txheej txheem thiab cov khoom siv.
Kuj tseem muaj cov teeb meem ntsig txog kev txheeb xyuas cov ntaub ntawv.Ib MTR (Kev Ntsuas Cov Khoom Siv) yog ib nqe lus los ntawm cov chaw tsim khoom casting uas sau cov txheej txheem casting thiab xyuas kom meej tias nws los ntawm ib qho kev khiav hauv cov txheej txheem casting.Qhov kev sib tw no yog qhov xav tau nyob rau hauv txhua qhov tseem ceeb ntawm cov kav dej sib txuas hauv ntau qhov kev lag luam.Txhua qhov khoom siv rau kev siv tshuaj yuav tsum muaj MTR txuas.
Lub rooj zaum cov khoom lag luam muab cov ntaub ntawv qhia muaj pes tsawg leeg los xyuas kom meej lub rooj zaum ua raws li FDA cov lus qhia.(FDA/USP Class VI) Cov ntaub ntawv siv tau muaj xws li PTFE, RTFE, Kel-F thiab TFM.
Ultra High Purity (UHP) yog ib lo lus uas yuav tsum tau hais txog qhov yuav tsum tau muaj kev purity siab heev.Qhov no yog ib lo lus uas tau siv dav hauv kev lag luam semiconductor uas yuav tsum muaj tsawg kawg nkaus ntawm cov khoom hauv cov kwj deg.Valves, piping, lim, thiab ntau cov ntaub ntawv siv hauv lawv cov kev tsim kho feem ntau ua tau raws li qib UHP no thaum npaj, ntim, thiab ua raws li cov xwm txheej tshwj xeeb.
Kev lag luam semiconductor muab cov qauv tsim los ntawm kev sib sau ua ke ntawm cov ntaub ntawv tswj hwm los ntawm SemaSpec pawg.Kev tsim cov microchip wafers yuav tsum tau ua raws li cov qauv nruj heev kom tshem tawm lossis txo qhov paug ntawm cov khoom, tawm thiab ya raws.
Tus txheej txheem SemaSpec qhia meej txog qhov chaw ntawm cov khoom tsim, qhov loj me, cov pa roj (los ntawm kev sib dhos mos), helium leak test, thiab noo noo nyob rau hauv thiab sab nraum lub valve ciam teb.
Pob li qub tau raug pov thawj zoo hauv cov ntawv siv tawv tshaj plaws.Qee qhov txiaj ntsig tseem ceeb ntawm qhov tsim no suav nrog:
Mechanical Polishing - Polished nto, welds thiab nto nyob rau hauv kev siv muaj txawv deg yam ntxwv thaum saib nyob rau hauv ib tug magnifying iav.Mechanical polishing txo tag nrho cov nto ridges, pits thiab variances mus rau ib tug uniform roughness.
Cov tshuab polishing yog ua tiav ntawm cov khoom siv sib hloov siv alumina abrasives.Mechanical polishing tuaj yeem ua tiav los ntawm cov cuab yeej tes rau thaj chaw loj, xws li cov reactors thiab cov hlab ntsha nyob rau hauv qhov chaw, los yog tsis siv neeg reciprocators rau cov kav dej los yog tubular qhov chaw.
Electropolishing yog kev tshem tawm ntawm cov microscopic irregularities los ntawm hlau nto los ntawm electrochemical txoj kev.Nws ua rau ib tug dav flatness los yog smoothness ntawm lub nto uas, thaum saib nyob rau hauv ib tug magnifying iav, zoo li yuav luag featureless.
Stainless hlau yog ib txwm tiv taus corrosion vim nws cov ntsiab lus chromium siab (feem ntau yog 16% lossis ntau dua hauv stainless hlau).Electropolishing txhim kho qhov kev tiv thaiv ntuj no vim tias cov txheej txheem yaj ntau hlau (Fe) dua li chromium (Cr).Qhov no tawm ntau dua chromium ntawm stainless hlau nto.(passivation)
Qhov tshwm sim ntawm cov txheej txheem polishing yog qhov tsim ntawm "nruj" nto txhais raws li qhov nruab nrab roughness (Ra).Raws li ASME / BPE; "Txhua qhov polishes yuav tsum tau qhia hauv Ra, microinches (m-in), lossis micrometers (mm)."
Qhov saum npoo du yog feem ntau ntsuas nrog lub profileometer, ib qho cuab yeej tsis siv neeg nrog lub ntsej muag stylus-style reciprocating caj npab.Lub stylus yog dhau los ntawm cov hlau nto los ntsuas qhov siab siab thiab hav tob.Qhov nruab nrab ntawm qhov siab thiab hav tob yog ces qhia raws li qhov nruab nrab roughness, nthuav tawm hauv millionths ntawm ib nti lossis microinches, feem ntau hu ua Ra.
Kev sib raug zoo ntawm polished thiab polished nto, tus naj npawb ntawm abrasive grains thiab nto roughness (ua ntej thiab tom qab electropolishing) yog qhia nyob rau hauv cov lus hauv qab no.(Rau ASME/BPE derivation, saib Table SF-6 nyob rau hauv daim ntawv no)
Micrometers yog ib hom European qauv, thiab cov metric system yog sib npaug rau microinches.Ib lub microinch yog sib npaug li 40 micrometers.Piv txwv: Ib qho tiav raws li 0.4 microns Ra yog sib npaug rau 16 micro inches Ra.
Vim yog qhov yooj yim ntawm lub pob valve tsim, nws tau yooj yim muaj nyob rau hauv ntau lub rooj zaum, foob thiab lub cev cov ntaub ntawv.Yog li ntawd, pob li qub tau tsim los tswj cov dej hauv qab no:
Kev lag luam biopharmaceutical nyiam rau nruab "lub kaw lus kaw lus" thaum twg ua tau.Extended Tube Outside Diameter (ETO) kev sib txuas yog nyob rau hauv-kab welded kom tshem tawm cov paug tawm sab nraud ntawm lub valve / yeeb nkab ciam teb thiab ntxiv nruj rau cov kav dej.Tri-Clamp (kev sib txuas ntawm lub cev) xaus ntxiv yooj yim rau lub kaw lus. disassembled thiab reconfigured.
Cherry-Burrell fittings nyob rau hauv lub npe "I-Line", "S-Line" los yog "Q-Line" kuj muaj nyob rau hauv siab purity systems xws li cov zaub mov / dej haus kev lag luam.
Extended Tube Sab Nraud Diameter (ETO) xaus tso cai rau hauv-kab vuam ntawm lub valve rau hauv cov kav dej.ETO xaus yog qhov loj kom haum rau cov yeeb nkab (pipe) kab kab thiab phab ntsa thickness.Lub raj ntev ntev haum rau orbital weld hau thiab muab ntev txaus los tiv thaiv kev puas tsuaj rau lub valve lub cev foob vim vuam kub.
Cov pob li qub tau siv dav hauv cov txheej txheem kev siv vim tias lawv qhov kev ua tau zoo tshaj plaws.Diaphragm li qub tau txwv qhov kub thiab txias kev pabcuam thiab tsis ua tau raws li txhua tus qauv rau kev lag luam li qub.Pob li qub tuaj yeem siv rau:
Tsis tas li ntawd, lub pob valve chaw nruab nrab yog tshem tau los tso cai rau kev nkag mus rau hauv cov hlaws dai, uas tuaj yeem ntxuav thiab / lossis polished.
Cov dej ntws tawm yog ib qho tseem ceeb kom ua kom cov txheej txheem bioprocessing nyob rau hauv huv si thiab tsis muaj menyuam.Cov kua uas seem tom qab tso dej dhau los ua qhov chaw colonization rau cov kab mob lossis lwm yam kab mob, tsim kom muaj cov bioburden uas tsis tuaj yeem siv rau ntawm qhov system.Qhov chaw uas cov kua dej tsim tuaj kuj tuaj yeem ua qhov chaw pib corrosion, ntxiv cov kab mob ntxiv rau hauv qhov system.Qhov tsim ntawm ASME / BMPE tus qauv yuav tsum tau tsim kom muaj cov txheej txheem tsim los ntawm cov khoom siv. kev tso dej tiav lawm.
Qhov chaw tuag hauv cov kav dej tau txhais tias yog qhov zawj, tee, lossis txuas ntxiv los ntawm cov yeeb nkab tseem ceeb khiav uas ntau tshaj li cov yeeb nkab txoj kab uas hla (L) uas tau teev tseg hauv cov yeeb nkab loj ID (D) Qhov chaw tuag yog qhov tsis xav tau vim tias nws muab thaj chaw nkag uas tsis tuaj yeem nkag los ntawm kev ntxuav lossis ntxuav cov txheej txheem, uas ua rau cov khoom sib kis tau. valve thiab piping configurations.
Cov hluav taws kub dampers yog tsim los tiv thaiv kev sib kis ntawm cov kua hluav taws xob thaum muaj cov txheej txheem kab hluav taws.Cov qauv tsim siv lub rooj zaum hlau rov qab thiab tiv thaiv zoo li qub los tiv thaiv ignition.Lub biopharmaceutical thiab cosmetic industries feem ntau nyiam cov hluav taws kub dampers hauv kev xa dej cawv.
FDA-USP23, Chav Kawm VI pom zoo pob valve cov ntaub ntawv suav nrog: PTFE, RTFE, Kel-F, PEEK thiab TFM.
TFM yog ib qho kev hloov kho PTFE uas txuas qhov sib txawv ntawm ib txwm PTFE thiab yaj-processable PFA.TFM yog cais raws li PTFE raws li ASTM D 4894 thiab ISO Draft WDT 539-1.5.Piv rau ib txwm PTFE, TFM muaj cov nram qab no enhanced zog:
Cavity-filled rooj zaum yog tsim los tiv thaiv buildup ntawm cov ntaub ntawv uas, thaum dai ntawm lub pob thiab lub cev kab noj hniav, yuav solidify los yog txwv tsis pub txoj kev ua haujlwm du ntawm lub valve kaw cov tswv cuab.High-purity pob li qub siv nyob rau hauv chav pab yuav tsum tsis txhob siv qhov kev xaiv lub rooj zaum, raws li chav yuav nrhiav tau nws txoj kev nyob rau hauv lub rooj zaum nto thiab ua ib qho chaw rau cov kab mob loj hlob.Vim hais tias ntawm no cov kab noj hniav yog qhov nyuaj heev. dismantling.
Pob li qub muaj nyob rau hauv qeb ntawm "rotary li qub".Rau kev ua haujlwm tsis siv neeg, ob hom actuators muaj: pneumatic thiab hluav taws xob.Pneumatic actuators siv lub piston lossis diaphragm txuas nrog lub tshuab tig xws li khib thiab pinion kev npaj los muab kev sib hloov cov zis torques thiab cov khoom siv hluav taws xob muaj ntau yam. Cov kev xaiv kom haum rau pob li qub.Yog xav paub ntxiv txog cov ncauj lus no, saib "Yuav Ua Li Cas Xaiv Lub Pob Valve Actuator" tom qab hauv phau ntawv no.
High Purity Ball Valves tuaj yeem ntxuav thiab ntim rau BPE lossis Semiconductor (SemaSpec) cov cai.
Kev tu yooj yim yog ua los ntawm kev siv lub tshuab ntxuav ultrasonic uas siv cov tshuaj alkaline reagent rau kev ntxuav txias thiab degreasing, nrog cov mis tsis muaj residue.
Cov khoom uas muaj qhov siab siab yog cim nrog tus lej cua sov thiab nrog rau daim ntawv pov thawj tsim nyog ntawm kev soj ntsuam.A Mill Test Report (MTR) tau sau tseg rau txhua qhov loj thiab cov xov tooj cua sov.Cov ntaub ntawv no suav nrog:
Qee lub sij hawm cov txheej txheem engineers yuav tsum xaiv ntawm pneumatic lossis hluav taws xob li qub rau cov txheej txheem tswj cov txheej txheem.Ob hom actuators muaj qhov zoo thiab nws tseem ceeb heev kom muaj cov ntaub ntawv muaj los ua qhov kev xaiv zoo tshaj plaws.
Thawj txoj haujlwm hauv kev xaiv hom actuator (pneumatic lossis hluav taws xob) yog los txiav txim siab lub zog siv hluav taws xob zoo tshaj plaws rau tus actuator.Cov ntsiab lus tseem ceeb yuav tsum xav txog yog:
Cov pneumatic actuators feem ntau siv cov cua siab ntawm 40 mus rau 120 psi (3 mus rau 8 bar). Feem ntau, lawv muaj qhov loj me rau cov khoom siv siab ntawm 60 mus rau 80 psi (4 mus rau 6 bar). Cov cua siab dua feem ntau nyuaj rau lav, thaum qis cua siab xav tau cov kab loj loj pistons lossis diaphragms los tsim.
Hluav taws xob actuators feem ntau yog siv nrog 110 VAC lub zog, tab sis tuaj yeem siv nrog ntau yam AC thiab DC motors, ob qho tib si thiab peb theem.
Qhov kub thiab txias.Ob lub pneumatic thiab hluav taws xob actuators tuaj yeem siv ntau qhov kub thiab txias.Qhov ntsuas kub ntawm pneumatic actuators yog -4 txog 1740F (-20 txog 800C), tab sis tuaj yeem txuas mus rau -40 txog 2500F (-40 txog 1210C) nrog kev xaiv cov ntsaws ruaj ruaj. thiab lwm yam) yog siv, lawv yuav tsum ntsuas kub txawv dua li tus actuator, thiab qhov no yuav tsum tau muab coj mus rau hauv tus account nyob rau hauv tag nrho cov kev siv.In low temperature applications, air supply quality in relation to dew point yuav tsum raug xam.Dew point yog qhov kub ntawm qhov condensation tshwm sim nyob rau hauv cov huab cua.Condensation tuaj yeem khov thiab thaiv cov khoom siv cua, tiv thaiv lub actuator los ntawm kev ua haujlwm.
Hluav taws xob actuators muaj qhov kub ntawm -40 txog 1500F (-40 txog 650C).Thaum siv sab nraum zoov, lub tshuab hluav taws xob yuav tsum raug cais tawm ntawm ib puag ncig kom tsis txhob ya raws los ntawm kev ua haujlwm sab hauv.Yog tias condensation yog rub los ntawm lub hwj chim conduit, condensation tseem tuaj yeem tsim sab hauv, uas tej zaum yuav tau sau cov dej nag hauv ib puag ncig kom tsis txhob ya raws los ntawm kev ua haujlwm sab hauv. thiab txias nws thaum nws tsis khiav, qhov kub hloov pauv tuaj yeem ua rau ib puag ncig "ua pa" thiab condense.Yog li ntawd, tag nrho cov hluav taws xob actuators rau kev siv sab nraum zoov yuav tsum tau nruab nrog lub rhaub.
Nws yog qee zaum nyuaj rau kev pom zoo rau kev siv hluav taws xob actuators hauv qhov chaw muaj kev phom sij, tab sis yog tias cov cua compressed lossis pneumatic actuators tsis tuaj yeem muab cov yam ntxwv ntawm kev ua haujlwm, cov hluav taws xob hluav taws xob nrog cov vaj tse tsim nyog yuav siv tau.
Lub koom haum National Electrical Manufacturers Association (NEMA) tau tsim cov txheej txheem rau kev tsim kho thiab kev teeb tsa ntawm cov hluav taws xob actuators (thiab lwm yam khoom siv hluav taws xob) rau kev siv hauv thaj chaw muaj kev phom sij.Cov lus qhia NEMA VII yog raws li hauv qab no:
VII Hazardous Location Class I (Explosive Gas or Vapor) Ua tau raws li National Electrical Code rau daim ntawv thov; Ua tau raws li cov kev qhia tshwj xeeb ntawm Underwriters' Laboratories, Inc. rau kev siv roj av, hexane, naphtha, benzene, butane, propane, acetone, Atmospheres of benzene, lacquer solvent vapors thiab natural gas.
Yuav luag tag nrho cov hluav taws xob actuator manufacturers muaj kev xaiv ntawm NEMA VII raws li cov qauv ntawm lawv cov qauv khoom kab.
Ntawm qhov tod tes, pneumatic actuators yog inherently tawg-pov thawj.Thaum hluav taws xob tswj tau siv nrog pneumatic actuators nyob rau hauv qhov chaw muaj kev phom sij, lawv feem ntau raug nqi ntau dua li hluav taws xob actuators.Lub solenoid-ua haujlwm tsav valve tuaj yeem ntsia tau rau hauv qhov chaw tsis muaj kev phom sij thiab piped mus rau qhov kev hloov pauv hauv NEMA - Li actuator. enclosures.Qhov kev nyab xeeb ntawm pneumatic actuators nyob rau hauv qhov chaw muaj kev phom sij ua rau lawv xaiv qhov kev xaiv zoo hauv cov ntawv thov no.
Lub caij nplooj ntoos hlav rov qab.Lwm kev ruaj ntseg accessory uas yog dav siv nyob rau hauv lub valve actuators nyob rau hauv cov txheej txheem kev lag luam yog lub caij nplooj ntoos hlav rov qab (tsis ua hauj lwm zoo) xaiv.Thaum lub sij hawm ntawm lub hwj chim los yog lub teeb liab tsis ua hauj lwm, lub caij nplooj ntoos hlav rov qab actuator tsav lub valve mus rau ib tug predetermined txoj hauj lwm zoo.
Yog tias lub caij nplooj ntoos hlav tsis tuaj yeem siv vim qhov loj ntawm lub actuator lossis qhov hnyav, lossis yog tias muaj ob chav ua yeeb yam tau teeb tsa, lub accumulator tank tuaj yeem ntsia tau los khaws huab cua.